Die folgenden Gennamen und Gensymbole werden für Antigen Peroxiredoxin 1 über verschiedene Spezies hinweg verwendet:

peroxiredoxin 1 (PRDX1), peroxiredoxin 1 (Prdx1), peroxiredoxin 1 (prdx1), peroxiredoxin 2 (prdx2), thioredoxin peroxidase 2 (Jafrac2), thioredoxin peroxidase 2 (TPx2), thioredoxin peroxidase 2 (PY02747), thioredoxin peroxidase 2 (BCAN_B0712), Thioredoxin peroxidase 2 (BMEA_B0682)

Zu den weiteren Synonymen zählen:

PAG, PAGA, PAGB, PRX1, PRXI, MSP23, NKEFA, TDPX2, OSF3, Paga, PrxI, TDX2, TPxA, prx1, NkefA, OSF-3, PrdxI, Tdpx2, Hbp23, MGC108617, MGC80194, MGC84820, PRDX1, pag, paga, pagb, msp23, nkefa, tdpx2, cb58, prdx1, MGC92891, zgc:92891, wu:fq19b09, DPx4156, Jafrac-2, Prx4156, DmelCG1274, CG1274

Auf Proteinebene tauchen folgende Bezeichner für Antigen Peroxiredoxin 1 auf:

peroxiredoxin 1 – proliferation-associated gene A – natural killer-enhancing factor A – thioredoxin-dependent peroxide reductase 2 – peroxiredoxin-1 – OTTMUSP00000009955 – OTTMUSP00000009957 – OTTMUSP00000009958 – OTTMUSP00000009959 – thioredoxin peroxidase 2 – osteoblast specific factor 3 – osteoblast-specific factor 3 – macrophage 23 Kd stress protein – macrophage 23kDa stress protein – macrophase stress protein 22kDa – macrophase stress protein 23 kd – macrophage 23 kDa stress protein – Trx dependent peroxide reductase 2 – thioredoxin dependent peroxide reductase 2 – heme-binding 23 kDa protein – peroxiredoxin 2 – thioredoxin peroxidase 2, isoform A – CG1274-PA – Jafrac2-PA – peroxiredoxin 4156 – jafrac2 – thioredoxin peroxidase – thioredoxin peroxidase 2, isoform B – CG1274-PB – Jafrac2-PB – Thioredoxin peroxidase 2

Peroxiredoxin 1 erfüllt eine Reihe von Funktionen:

oxidoreductase activity – protein binding – thioredoxin peroxidase activity – antioxidant activity – heme binding – peroxidase activity – peroxiredoxin activity – protein homodimerization activity

Peroxiredoxin 1 spielt in den folgenden Prozessen eine Rolle:

cell proliferation – cell redox homeostasis – hydrogen peroxide catabolic process – oxidation reduction – skeletal system development – erythrocyte homeostasis – natural killer cell mediated cytotoxicity – regulation of NF-kappaB import into nucleus – regulation of stress-activated MAPK cascade – removal of superoxide radicals – response to oxidative stress – response to reactive oxygen species – apoptosis – cellular response to DNA damage stimulus – induction of apoptosis

Peroxiredoxin 1 ist wie folgt lokalisiert:

cytoplasm – melanosome – mitochondrion – nucleus – cytosol – mitochondrial matrix – nuclear euchromatin – nucleolus – peroxisomal matrix – extracellular region

Quelle: NCBI Entrez Gene, Gene Ontology