Die folgenden Gennamen und Gensymbole werden für Antigen Patched 1 über verschiedene Spezies hinweg verwendet:

patched homolog 1 (Drosophila) (PTCH1), patched 1 (ptc1), patched homolog 1 (Drosophila) (Ptch1), patched homolog 1 (ptch1), patched (PTCH1), patched protein-like protein (PTCH1), patched 1 (PTCH1), patched 1 (ptch1)

Zu den weiteren Synonymen zählen:

PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11, FLJ26746, FLJ42602, ptc-1, ptch1, Ptch, Ptch2, ptc1, XPtc1, patched, patched1, PTCH1

Auf Proteinebene tauchen folgende Bezeichner für Antigen Patched 1 auf:

patched – PTCH protein +4' – PTCH protein -10 – PTCH protein +12b – OTTHUMP00000021709 – OTTHUMP00000021710 – protein patched homolog 1 – blw – blowout – etID309849.2 – patched homolog 2 – patched homolog 1 – patched-1 – patched homolog 1 (Drosophila) – patched protein-like protein – patched 1 – patched-like – protein patched homolog 1-like

Patched 1 erfüllt eine Reihe von Funktionen:

hedgehog receptor activity – protein binding – receptor activity – heparin binding – molecular_function – patched binding

Patched 1 spielt in den folgenden Prozessen eine Rolle:

cell proliferation – dorsal/ventral pattern formation – embryonic limb morphogenesis – negative regulation of multicellular organism growth – organ morphogenesis – protein processing – regulation of smoothened signaling pathway – signal transduction – camera-type eye development – cardioblast differentiation – negative regulation of muscle organ development – proximal/distal pattern formation – retinal ganglion cell axon guidance – smoothened signaling pathway – dorsal/ventral neural tube patterning – epidermis development – glucose homeostasis – heart morphogenesis – hindlimb morphogenesis – keratinocyte proliferation – mammary gland development – mammary gland duct morphogenesis – mammary gland epithelial cell differentiation – negative regulation of epithelial cell proliferation – neural tube closure – neural tube formation – pattern specification process – regulation of growth – response to chlorate – response to drug – response to estradiol stimulus – response to mechanical stimulus – response to organic cyclic substance – response to retinoic acid

Patched 1 ist wie folgt lokalisiert:

integral to plasma membrane – membrane – integral to membrane – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology