Die folgenden Gennamen und Gensymbole werden für Antigen Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) über verschiedene Spezies hinweg verwendet:

Parkinson disease (autosomal recessive, juvenile) 2, parkin (PARK2), parkin (park), Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2), Parkinson disease (autosomal recessive, juvenile) 2, parkin (park2), parkin (PARK2), parkin (CpipJ_CPIJ014867), Parkinson disease (autosomal recessive, juvenile) 2, parkin (LOC100150461)

Zu den weiteren Synonymen zählen:

PDJ, PRKN, AR-JP, LPRS2, SD01679, dpk, Dmel\CG10523, CG10523, Park, Prkn, zgc:112390, PARK2, pdr-1, LOC100150461

Auf Proteinebene tauchen folgende Bezeichner für Antigen Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) auf:

parkin – parkin 2 – E3 ubiquitin ligase – parkin, isoform B – CG10523-PB – park-PB – dParkin – D-parkin – parkin, isoform C – CG10523-PC – park-PC – E3 ubiquitin-protein ligase parkin – Parkinson disease (autosomal recessive, juvenile) 2, parkin

Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) erfüllt eine Reihe von Funktionen:

acid-amino acid ligase activity – ligase activity – metal ion binding – protein binding – ubiquitin-protein ligase activity – zinc ion binding – methyltransferase activity – nucleic acid binding – ubiquitin conjugating enzyme binding – PDZ domain binding – chaperone binding – kinase binding – protein complex binding – hydrolase activity

Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) spielt in den folgenden Prozessen eine Rolle:

central nervous system development – protein ubiquitination during ubiquitin-dependent protein catabolic process – methylation – mitochondrial fission – mitochondrion organization – negative regulation of JNK cascade – protein autoubiquitination – protein ubiquitination – response to oxidative stress – spermatogenesis – adult locomotory behavior – aggresome assembly – dopamine metabolic process – dopamine uptake – learning – locomotory behavior – negative regulation of actin filament bundle assembly – negative regulation of cell death – negative regulation of protein amino acid phosphorylation – negative regulation of release of cytochrome c from mitochondria – neuron maturation – norepinephrine metabolic process – positive regulation of I-kappaB kinase/NF-kappaB cascade – protein K63-linked ubiquitination – protein metabolic process – protein modification process – protein polyubiquitination – protein ubiquitination involved in ubiquitin-dependent protein catabolic process – regulation of neurotransmitter secretion – regulation of oxygen and reactive oxygen species metabolic process – regulation of synaptic transmission – response to corticosterone stimulus – response to drug – response to unfolded protein – startle response – synaptic transmission, dopaminergic – synaptic transmission, glutamatergic – ubiquitin-dependent protein catabolic process – mitochondrial electron transport, NADH to ubiquinone

Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) ist wie folgt lokalisiert:

Golgi apparatus – cytoplasm – nucleus – perinuclear region of cytoplasm – Golgi membrane – aggresome – cell junction – cell projection – cytoplasmic vesicle – cytosol – dendrite – endoplasmic reticulum – intracellular – membrane raft – neuron projection – plasma membrane – postsynaptic density – postsynaptic membrane – protein complex – synapse – synaptic vesicle – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology