Die folgenden Gennamen und Gensymbole werden für Antigen Paired Box 6 über verschiedene Spezies hinweg verwendet:

paired box 6 (PAX6), paired box gene 6 (Pax6), paired box 6 (Pax6), paired box 6 (pax6), paired domain transcription factor variant B (pax6b), paired box gene 6 (PAX6)

Zu den weiteren Synonymen zählen:

AN, AN2, MGDA, WAGR, D11S812E, MGC17209, Dey, Sey, AEY11, Pax-6, Gsfaey11, 1500038E17Rik, pax-6, an2, mgda, wagr, pax6a, xpax6, XLPAX6, MGC52531, PAX6, pax6, pax6b, PAX-6

Auf Proteinebene tauchen folgende Bezeichner für Antigen Paired Box 6 auf:

paired box gene 6 – OTTHUMP00000038834 – OTTHUMP00000038836 – OTTHUMP00000038837 – OTTHUMP00000038838 – OTTHUMP00000038839 – OTTHUMP00000038840 – paired box homeotic gene-6 – paired box protein Pax-6 – small eye – oculorhombin – Dickie's small eye – OTTMUSP00000015972 – OTTMUSP00000015975 – OTTMUSP00000015976 – OTTMUSP00000015977 – OTTMUSP00000015978 – OTTMUSP00000015979 – OTTMUSP00000015980 – paired box homeotic gene 6 – paired box gene 6 (aniridia, keratitis) – paired box 6 – paired box gene 6 a – paired box gene 6 b – paired-type homeodomain Pax-6 protein

Paired Box 6 erfüllt eine Reihe von Funktionen:

protein binding – sequence-specific DNA binding – transcription factor activity – AT DNA binding – DNA binding – RNA polymerase II transcription factor activity – double-stranded DNA binding – promoter binding – sequence-specific DNA binding transcription factor activity – transcription regulator activity

Paired Box 6 spielt in den folgenden Prozessen eine Rolle:

cell differentiation – central nervous system development – eye development – multicellular organismal development – organ morphogenesis – regulation of transcription, DNA-dependent – visual perception – anterior/posterior pattern formation – astrocyte differentiation – axon guidance – axonogenesis – brain development – camera-type eye development – cell fate commitment – cell fate determination – commitment of a neuronal cell to a specific type of neuron in the forebrain – dorsal/ventral axis specification – dorsal/ventral pattern formation – eye photoreceptor cell development – forebrain anterior/posterior pattern formation – forebrain development – forebrain dorsal/ventral pattern formation – forebrain-midbrain boundary formation – hindbrain development – keratinocyte differentiation – lacrimal gland development – lens development in camera-type eye – negative regulation of cell proliferation – negative regulation of epithelial cell proliferation – negative regulation of neuron differentiation – neuron migration – oligodendrocyte cell fate specification – pallium development – pituitary gland development – positive regulation of cell fate specification – positive regulation of epithelial cell differentiation – positive regulation of neuroblast proliferation – positive regulation of transcription from RNA polymerase II promoter – protein localization in organelle – regulation of cell migration – regulation of epithelial cell proliferation – regulation of gene expression – regulation of gene-specific transcription from RNA polymerase II promoter – regulation of neurogenesis – regulation of neuron differentiation – regulation of timing of cell differentiation – regulation of transcription – regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment – regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification – regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification – salivary gland morphogenesis – smoothened signaling pathway – transcription – transcription from RNA polymerase II promoter – response to wounding

Paired Box 6 ist wie folgt lokalisiert:

nucleus – intracellular – intracellular part – transcription factor complex – cytoplasm

Quelle: NCBI Entrez Gene, Gene Ontology