Die folgenden Gennamen und Gensymbole werden für Antigen PDZ Domain Containing 3 über verschiedene Spezies hinweg verwendet:

PDZ domain containing 3 (PDZD3), PDZ domain containing 3 (Pdzd3), PDZ domain containing 2 (PDZD2), PDZ domain containing 2 (Pdzd2), PDZ domain containing 3b (pdzd3b)

Zu den weiteren Synonymen zählen:

IKEPP, PDZK2, NHERF4, FLJ22756, Pdzk2, NaPi-Cap2, AIPC, PIN1, PAPIN, PDZK3, KIAA0300, Papin, Pdzk3, zgc:194812

Auf Proteinebene tauchen folgende Bezeichner für Antigen PDZ Domain Containing 3 auf:

Na(+)/H(+) exchange regulatory cofactor NHE-RF4 – NHERF-4 – naPi-Cap2 – PDZ domain containing 2 – PDZ domain-containing protein 2 – PDZ domain-containing protein 3 – intestinal and kidney enriched PDZ protein – intestinal and kidney-enriched PDZ protein – sodium-hydrogen exchanger regulatory factor 4 – na/Pi cotransporter C-terminal-associated protein 2 – natrium-phosphate cotransporter IIa C-terminal-associated protein 2 – PDZ domain containing 3 – sodium-phosphate cotransporter IIa C-terminal-associated protein 2 – activated in prostate cancer protein – plakophilin-related armadillo repeat protein-interacting PDZ protein-like

PDZ Domain Containing 3 erfüllt eine Reihe von Funktionen:

guanylate cyclase inhibitor activity – ion channel inhibitor activity – protein C-terminus binding – protein binding – PDZ domain binding

PDZ Domain Containing 3 spielt in den folgenden Prozessen eine Rolle:

cGMP-mediated signaling – ion transport – negative regulation of cGMP biosynthetic process – receptor guanylyl cyclase signaling pathway – response to toxin – water transport – apical part of cell – brush border – cytoplasm – endosome – membrane – cell adhesion – intracellular signaling cascade – carnitine transport – positive regulation of ion transmembrane transport

PDZ Domain Containing 3 ist wie folgt lokalisiert:

apical part of cell – brush border – cytoplasm – cytosol – membrane fraction – plasma membrane – subapical complex – cell-cell junction – endoplasmic reticulum – extracellular region – nucleus – cell junction – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology