Die folgenden Gennamen und Gensymbole werden für Antigen P21-Activated Kinases 1/2/3 über verschiedene Spezies hinweg verwendet:

p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), p21 GTPase-associated kinase 1 (PAK1)

Zu den weiteren Synonymen zählen:

PAKalpha, MGC130000, MGC130001, Paka, PAK-1, AW045634, PAK1, MGC83445, MGC139676

Auf Proteinebene tauchen folgende Bezeichner für Antigen P21-Activated Kinases 1/2/3 auf:

p21-activated kinase 1 – STE20 homolog, yeast – p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) – p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) – serine/threonine-protein kinase PAK 1 – p65-PAK – alpha-PAK – OTTMUSP00000023295 – activated protein kinase alpha – CDC42/RAC effector kinase PAK-A – PAK-1 – p68-PAK – protein kinase MUK2 – p21 (CDKN1A)-activated kinase 1 – p21 protein (Cdc42/Rac)-activated kinase 1 – putative CDKN1A-activated kinase 1

P21-Activated Kinases 1/2/3 erfüllt eine Reihe von Funktionen:

ATP binding – collagen binding – nucleotide binding – protein serine/threonine kinase activity – transferase activity – kinase activity – protein binding – protein kinase activity – protein kinase binding – MAP kinase kinase kinase activity

P21-Activated Kinases 1/2/3 spielt in den folgenden Prozessen eine Rolle:

ER-nuclear signaling pathway – MAPKKK cascade – apoptosis – cytoskeleton organization – positive regulation of JUN kinase activity – protein amino acid autophosphorylation – cellular response to insulin stimulus – cellular response to stress – dendrite development – neuromuscular junction development – neuron projection morphogenesis – phosphorylation – protein amino acid phosphorylation – receptor clustering – regulation of actin cytoskeleton organization – response to hypoxia – response to organic substance – intracellular protein kinase cascade – small GTPase mediated signal transduction

P21-Activated Kinases 1/2/3 ist wie folgt lokalisiert:

Golgi apparatus – cell junction – cytoplasm – focal adhesion – plasma membrane – Z disc – axon – cytosol – dendrite – growth cone – intercalated disc – membrane fraction – nuclear membrane – nucleus

Quelle: NCBI Entrez Gene, Gene Ontology