Die folgenden Gennamen und Gensymbole werden für Antigen Neuregulin 1 über verschiedene Spezies hinweg verwendet:

neuregulin 1 (NRG1), neuregulin 1 (Nrg1), neuregulin 4 (NRG4), neuregulin 1 (nrg1-A), neuregulin 1 (nrg1)

Zu den weiteren Synonymen zählen:

GGF, HGL, HRG, NDF, ARIA, GGF2, HRG1, HRGA, SMDF, HRG4, DKFZp779N0541, DKFZp779N1944, Hgl, GGFII, HRGalpha, 6030402G23Rik, D230005F13Rik, NRG1, MGC154949, nrg1-A, nrg1, NRG-1, wu:fm70e01, DKFZp459A1838

Auf Proteinebene tauchen folgende Bezeichner für Antigen Neuregulin 1 auf:

neuregulin 1 – glial growth factor – neu differentiation factor – sensory and motor neuron derived factor – heregulin, alpha (45kD, ERBB2 p185-activator) – pro-neuregulin-1, membrane-bound isoform – pro-NRG1 – neuregulin 1 type III beta 3 – neuregulin 4 – heregulin 4 – heregulin – type I neuregulin 1 – type III neuregulin 1 – Pro-neuregulin-1, membrane-bound isoform – HRG-alpha – heregulin-alpha – neuregulin 1 alpha isoform

Neuregulin 1 erfüllt eine Reihe von Funktionen:

growth factor activity – receptor tyrosine kinase binding – transcription cofactor activity – transmembrane receptor protein tyrosine kinase activator activity – ErbB-2 class receptor binding – ErbB-3 class receptor binding – protein binding – protein tyrosine kinase activator activity – receptor binding

Neuregulin 1 spielt in den folgenden Prozessen eine Rolle:

Notch signaling pathway – cardiac muscle cell differentiation – cell communication – cellular protein complex disassembly – embryonic development – mammary gland development – negative regulation of secretion – negative regulation of transcription – nervous system development – neural crest cell development – positive regulation of striated muscle cell differentiation – regulation of protein heterodimerization activity – regulation of protein homodimerization activity – wound healing – MAPKKK cascade – activation of transmembrane receptor protein tyrosine kinase activity – anti-apoptosis – cell migration – cell morphogenesis – cell proliferation – embryo development – glial cell differentiation – glucose transport – heart development – locomotory behavior – muscle organ development – myelination – negative regulation of cardiac muscle cell apoptosis – neuron fate commitment – neurotransmitter receptor metabolic process – peripheral nervous system development – positive regulation of Ras protein signal transduction – positive regulation of cardiac muscle cell proliferation – positive regulation of cell adhesion – positive regulation of cell growth – positive regulation of protein kinase activity – regulation of blood pressure – regulation of cell differentiation – synapse assembly – transmembrane receptor protein tyrosine kinase signaling pathway – ventricular cardiac muscle cell differentiation – extracellular region – integral to membrane – plasma membrane – eurydendroid cell differentiation – neural crest cell migration – oligodendrocyte cell fate specification

Neuregulin 1 ist wie folgt lokalisiert:

extracellular region – integral to membrane – nucleus – plasma membrane – apical plasma membrane – cytoplasm – extracellular space – integral to plasma membrane – synapse – membrane

Quelle: NCBI Entrez Gene, Gene Ontology