Die folgenden Gennamen und Gensymbole werden für Antigen Mitogen-Activated Protein Kinase Kinase Kinase 1 über verschiedene Spezies hinweg verwendet:

mitogen-activated protein kinase kinase kinase 1 (MAP3K1), mitogen-activated protein kinase kinase kinase 1 (Map3k1), mitogen activated protein kinase kinase kinase 1 (Map3k1), similar to MEK kinase 1 (MAP3K1), mitogen-activated protein kinase kinase kinase 1 (map3k1)

Zu den weiteren Synonymen zählen:

MEKK, MEKK1, MAPKKK1, Mekk, Mekk1, MAP3K1

Auf Proteinebene tauchen folgende Bezeichner für Antigen Mitogen-Activated Protein Kinase Kinase Kinase 1 auf:

mitogen-activated protein kinase kinase kinase 1 – MEK kinase 1 – MAP/ERK kinase kinase 1 – MAPK/ERK kinase kinase 1 – MEK kinase – OTTMUSP00000021865 – mitogen activated protein kinase kinase kinase 1

Mitogen-Activated Protein Kinase Kinase Kinase 1 erfüllt eine Reihe von Funktionen:

ATP binding – JUN kinase kinase activity – MAP kinase kinase kinase activity – identical protein binding – magnesium ion binding – nucleotide binding – protein serine/threonine kinase activity – transferase activity – zinc ion binding – kinase activity – metal ion binding – protein binding – protein kinase activity – JUN kinase binding – JUN kinase kinase kinase activity – MAP/ERK kinase kinase activity – mitogen-activated protein kinase binding – mitogen-activated protein kinase kinase binding – sphingolipid binding – ubiquitin-protein ligase activity

Mitogen-Activated Protein Kinase Kinase Kinase 1 spielt in den folgenden Prozessen eine Rolle:

I-kappaB kinase/NF-kappaB cascade – activation of JUN kinase activity – apoptotic mitochondrial changes – camera-type eye development – positive regulation of actin filament polymerization – protein amino acid phosphorylation – regulation of cell migration – transforming growth factor beta receptor signaling pathway – wound healing – JNK cascade – MAPKKK cascade – activation of JNKK activity – activation of MAPKK activity – negative regulation of actin filament bundle formation – peptidyl-serine phosphorylation – positive regulation of JUN kinase activity – positive regulation of MAP kinase activity – positive regulation of apoptosis – positive regulation of gene-specific transcription from RNA polymerase II promoter – positive regulation of viral transcription – protein amino acid autophosphorylation – protein oligomerization – protein polyubiquitination – protein ubiquitination during ubiquitin-dependent protein catabolic process – response to osmotic stress

Mitogen-Activated Protein Kinase Kinase Kinase 1 ist wie folgt lokalisiert:

cellular_component – cytosol – cytoplasm – cytoskeleton – extrinsic to membrane – membrane – membrane fraction

Quelle: NCBI Entrez Gene, Gene Ontology