Die folgenden Gennamen und Gensymbole werden für Antigen Mitogen-Activated Protein Kinase Kinase 4 über verschiedene Spezies hinweg verwendet:

mitogen-activated protein kinase kinase 4 (MAP2K4), mitogen-activated protein kinase kinase 4 (Map2k4), mitogen-activated protein kinase kinase 4 (map2k4), MAP kinase kinase 4 (Mkk4), CG12798 (CG12798), (CR12798)

Zu den weiteren Synonymen zählen:

JNKK, MEK4, MKK4, SEK1, JNKK1, SERK1, MAPKK4, PRKMK4, Sek1, Serk1, map2k4a, MGC136500, zgc:136500, jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CT27508, D-MKK4, DMKK4, JNKK2, Mpk4, SEK1/MKK4, DmelCG9738, CG9738, CT38386, DmelCG12798, CG12798, DmelCR12798

Auf Proteinebene tauchen folgende Bezeichner für Antigen Mitogen-Activated Protein Kinase Kinase 4 auf:

mitogen-activated protein kinase kinase 4 – MAPK/ERK kinase 4 – SAPK/ERK kinase 1 – MAP kinase kinase 4 – JNK-activated kinase 1 – JNK activating kinase 1 – c-Jun N-terminal kinase kinase 1 – dual specificity mitogen-activated protein kinase kinase 4 – MEK 4 – JNKK 1 – MAPKK 4 – JNK kinase 1 – SAPK/Erk/kinase 1 – OTTMUSP00000006102 – JNK-activating kinase 1 – C-JUN N-terminal kinase kinase 1 – mitogen activated protein kinase kinase 4, variant 1 – mitogen-activated protein kinase kinase 4A – CG9738-PA – Mkk4-PA – drosophila MAP kinase kinase 4 – JNK kinase 2 – CG12798 – CG12798-PA

Mitogen-Activated Protein Kinase Kinase 4 erfüllt eine Reihe von Funktionen:

ATP binding – nucleotide binding – protein binding – protein serine/threonine kinase activity – protein tyrosine kinase activity – transferase activity – JUN kinase kinase activity – MAP kinase kinase activity – kinase activity – mitogen-activated protein kinase kinase kinase binding – protein kinase activity – receptor signaling protein serine/threonine kinase activity

Mitogen-Activated Protein Kinase Kinase 4 spielt in den folgenden Prozessen eine Rolle:

JNK cascade – protein amino acid phosphorylation – signal transduction – MAPKKK cascade – activation of JUN kinase activity – positive regulation of DNA replication – positive regulation of apoptosis – positive regulation of neuron apoptosis – positive regulation of protein amino acid phosphorylation – determination of dorsal identity – protein phosphorylation

Mitogen-Activated Protein Kinase Kinase 4 ist wie folgt lokalisiert:

axon part – cytosol – dendrite cytoplasm – nucleus – perikaryon – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology