Die folgenden Gennamen und Gensymbole werden für Antigen Mitogen-Activated Protein Kinase Kinase 1 über verschiedene Spezies hinweg verwendet:

mitogen-activated protein kinase kinase 1 (MAP2K1), mitogen-activated protein kinase kinase 1 (Map2k1), mitogen activated protein kinase kinase 1 (Map2k1)

Zu den weiteren Synonymen zählen:

MEK1, MKK1, MAPKK1, PRKMK1, Mek1, MEKK1, Prkmk1

Auf Proteinebene tauchen folgende Bezeichner für Antigen Mitogen-Activated Protein Kinase Kinase 1 auf:

mitogen-activated protein kinase kinase 1 – protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) – dual specificity mitogen-activated protein kinase kinase 1 – MEK 1 – MAPKK 1 – MAPK/ERK kinase 1 – OTTMUSP00000018355 – MAP kinase kinase 1 – ERK activator kinase 1 – mitogen activated protein kinase kinase 1 – protein kinase, mitogen activated, kinase 1, p45 – MAP kinase/Erk kinase 1

Mitogen-Activated Protein Kinase Kinase 1 erfüllt eine Reihe von Funktionen:

ATP binding – MAP kinase kinase activity – nucleotide binding – protein binding – protein serine/threonine kinase activity – protein tyrosine kinase activity – receptor signaling protein tyrosine phosphatase activity – transferase activity – Ras GTPase binding – kinase activity – mitogen-activated protein kinase kinase kinase binding – protein kinase activity – protein kinase binding

Mitogen-Activated Protein Kinase Kinase 1 spielt in den folgenden Prozessen eine Rolle:

Ras protein signal transduction – cell motion – cell proliferation – chemotaxis – keratinocyte differentiation – mitosis – neuron differentiation – positive regulation of MAP kinase activity – positive regulation of cell differentiation – protein amino acid phosphorylation – response to glucocorticoid stimulus – response to oxidative stress – Golgi inheritance – MAPKKK cascade – activation of MAPK activity – cell motility – dephosphorylation – labyrinthine layer development – melanosome transport – negative regulation of homotypic cell-cell adhesion – neuron projection morphogenesis – placenta blood vessel development – positive regulation of RNA elongation from RNA polymerase II promoter – positive regulation of Ras GTPase activity – positive regulation of cell migration – protein heterooligomerization – regulation of vascular smooth muscle contraction – response to axon injury – vesicle transport along microtubule – cell cycle arrest – intracellular protein kinase cascade – negative regulation of cell proliferation – small GTPase mediated signal transduction

Mitogen-Activated Protein Kinase Kinase 1 ist wie folgt lokalisiert:

Golgi apparatus – cytosol – axon part – cell cortex – dendrite – dendrite cytoplasm – microtubule – perikaryon – perinuclear region of cytoplasm – plasma membrane – soluble fraction

Quelle: NCBI Entrez Gene, Gene Ontology