Die folgenden Gennamen und Gensymbole werden für Antigen Mitogen-Activated Protein Kinase 8 über verschiedene Spezies hinweg verwendet:

mitogen-activated protein kinase 8 (MAPK8), mitogen-activated protein kinase 8 (Mapk8), basket (bsk), Jun N-terminal Kinase (jnk-1), mitogen-activated protein kinase 8 (ATMPK8)

Zu den weiteren Synonymen zählen:

JNK, JNK1, PRKM8, SAPK1, JNK1A2, JNK21B1/2, Prkm8, AI849689, Bsk, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, JNK/SAPK, Junk, SAPKa, dJUN, DmelCG5680, CG5680, T10F20.15

Auf Proteinebene tauchen folgende Bezeichner für Antigen Mitogen-Activated Protein Kinase 8 auf:

mitogen-activated protein kinase 8 – OTTHUMP00000019552 – protein kinase JNK1 – JUN N-terminal kinase – JNK1 beta protein kinase – JNK1 alpha protein kinase – c-Jun N-terminal kinase 1 – stress-activated protein kinase JNK1 – mitogen-activated protein kinase 8 isoform JNK1 beta2 – mitogen-activated protein kinase 8 isoform JNK1 alpha1 – MAPK 8 – MAP kinase 8 – OTTMUSP00000019790 – OTTMUSP00000019791 – OTTMUSP00000019793 – OTTMUSP00000019794 – JNK1 beta1 protein kinase – mitogen activated protein kinase 8 – protein kinase mitogen-activated 8 – p54 gamma – SAPK gamma – c-jun NH2-terminal kinase – basket – CG5680-PB – bsk-PB – Jun-kinase – Jun-N-terminal kinase – JNK – Jun N-terminal kinase – Jun kinase – Jun N-terminal Kinase family member (jnk-1)

Mitogen-Activated Protein Kinase 8 erfüllt eine Reihe von Funktionen:

ATP binding – JUN kinase activity – MAP kinase activity – nucleotide binding – protein binding – protein serine/threonine kinase activity – transferase activity – kinase activity – protein kinase activity – calmodulin binding – phosphorylase kinase activity – protein tyrosine kinase activity

Mitogen-Activated Protein Kinase 8 spielt in den folgenden Prozessen eine Rolle:

JUN phosphorylation – activation of pro-apoptotic gene products – cell motion – induction of apoptosis by extracellular signals – negative regulation of apoptosis – response to UV – response to stress – signal transduction – JNK cascade – induction of apoptosis in response to chemical stimulus – inflammatory response – neuron projection development – ossification – peptidyl-threonine phosphorylation – positive regulation of DNA replication – positive regulation of cell migration – positive regulation of microtubule polymerization – protein amino acid phosphorylation – regulation of transcription, DNA-dependent – response to cadmium ion – response to heat – response to hydrogen peroxide – response to osmotic stress – apoptosis – positive regulation of apoptosis – response to steroid hormone stimulus – MAPKKK cascade – Wnt receptor signaling pathway – antibacterial humoral response – axon extension – border follicle cell migration – compound eye photoreceptor fate commitment – defense response – dorsal appendage formation – dorsal closure – embryonic morphogenesis – establishment of planar polarity – glycogen biosynthetic process – imaginal disc fusion, thorax closure – initiation of dorsal closure – micropyle formation – negative regulation of JUN kinase activity – ovarian follicle cell development – wound healing – wound healing, spreading of epidermal cells – hyperosmotic response – vesicle transport along actin filament – response to jasmonic acid stimulus – response to reactive oxygen species – response to wounding

Mitogen-Activated Protein Kinase 8 ist wie folgt lokalisiert:

cytosol – nucleoplasm – axon part – cytoplasm – dendrite cytoplasm – mitochondrion – nucleus – perikaryon – vesicle – phosphorylase kinase complex – plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology