Die folgenden Gennamen und Gensymbole werden für Antigen Microtubule-Associated Protein tau über verschiedene Spezies hinweg verwendet:

microtubule-associated protein tau (MAPT), microtubule-associated protein tau (Mapt), microtubule-associated protein tau (mapt), microtubule-associated protein tau (AaeL_AAEL015538), microtubule-associated protein tau (AaeL_AAEL012206), microtubule-associated protein tau (CpipJ_CPIJ013260), Microtubule-associated protein tau (tau)

Zu den weiteren Synonymen zählen:

TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549, Tau, Mtapt, AI413597, AW045860, pTau, RNPTAU, MGC156663, tau, MGC134287, xtp, MAPT

Auf Proteinebene tauchen folgende Bezeichner für Antigen Microtubule-Associated Protein tau auf:

microtubule-associated protein tau – microtubule-associated protein tau, isoform 4 – G protein beta1/gamma2 subunit-interacting factor 1 – PHF-tau – OTTMUSP00000003078 – OTTMUSP00000003079 – OTTMUSP00000003080 – OTTMUSP00000003083 – paired helical filament-tau – neurofibrillary tangle protein – Tau microtubule-associated protein – tau protein – microtubule associated protein tau – tau-like protein – tau-like protein-2 – Microtubule-associated protein tau

Microtubule-Associated Protein tau erfüllt eine Reihe von Funktionen:

SH3 domain binding – apolipoprotein E binding – enzyme binding – identical protein binding – lipoprotein binding – microtubule binding – structural constituent of cytoskeleton – protein binding – protein domain specific binding – protein kinase binding

Microtubule-Associated Protein tau spielt in den folgenden Prozessen eine Rolle:

generation of neurons – microtubule cytoskeleton organization – negative regulation of microtubule depolymerization – positive regulation of axon extension – positive regulation of microtubule polymerization – apoptosis – response to nutrient – response to organic substance – microtubule-based process – neuron differentiation

Microtubule-Associated Protein tau ist wie folgt lokalisiert:

axon – cell projection – cytoplasm – cytoskeleton – cytosol – growth cone – internal side of plasma membrane – microtubule – microtubule associated complex – plasma membrane – tubulin complex – axonal growth cone – cilium axoneme – membrane – neuron projection

Quelle: NCBI Entrez Gene, Gene Ontology