Die folgenden Gennamen und Gensymbole werden für Antigen Mechanistic Target of Rapamycin (serine/threonine Kinase) über verschiedene Spezies hinweg verwendet:

mechanistic target of rapamycin (serine/threonine kinase) (MTOR), mechanistic target of rapamycin (serine/threonine kinase) (Mtor), FK506 binding protein 12-rapamycin associated protein 1 (frap1), FK506 binding protein 12-rapamycin associated protein 1 (FRAP1), RAR-related orphan receptor C (RORC)

Zu den weiteren Synonymen zählen:

FRAP, FRAP1, FRAP2, RAFT1, RAPT1, FLJ44809, flat, Frap1, AI327068, MGC118056, 2610315D21Rik, tor, fc22h08, wu:fc22h08, MTOR, TOR, RORG, RZRG, NR1F3, MGC129539, RZR-GAMMA

Auf Proteinebene tauchen folgende Bezeichner für Antigen Mechanistic Target of Rapamycin (serine/threonine Kinase) auf:

FK506 binding protein 12-rapamycin associated protein 1 – rapamycin target protein – mammalian target of rapamycin – rapamycin and FKBP12 target 1 – FKBP-rapamycin associated protein – rapamycin associated protein FRAP2 – FKBP12-rapamycin complex-associated protein 1 – FK506 binding protein 12-rapamycin associated protein 2 – serine/threonine-protein kinase mTOR – OTTMUSP00000011776 – rapamycin target protein 1 – angiopoietin-like factor CDT6 – FKBP-rapamycin-associated protein FRAP – FKBP-rapamycin associated protein (FRAP) – FKBP12-rapamycin complex-associated protein – FK506-binding protein 12-rapamycin complex-associated protein 1 – RAPT1 – rapamycin and FKBP12 target-1 protein – target of rapamycin – mechanistic target of rapamycin (serine/threonine kinase) – RAR-related orphan receptor C – nuclear receptor ROR-gamma – RAR-related orphan receptor gamma – retinoic acid-binding receptor gamma – retinoid-related orphan receptor gamma – RAR-related orphan receptor C, isoform a

Mechanistic Target of Rapamycin (serine/threonine Kinase) erfüllt eine Reihe von Funktionen:

ATP binding – kinase activity – nucleotide binding – phosphoprotein binding – phosphotransferase activity, alcohol group as acceptor – protein serine/threonine kinase activity – binding – drug binding – protein binding – transferase activity – transferase activity, transferring phosphorus-containing groups – metal ion binding – sequence-specific DNA binding – steroid hormone receptor activity – transcription factor activity – zinc ion binding

Mechanistic Target of Rapamycin (serine/threonine Kinase) spielt in den folgenden Prozessen eine Rolle:

TOR signaling pathway – cell growth – protein amino acid autophosphorylation – protein catabolic process – regulation of actin cytoskeleton organization – response to amino acid stimulus – response to nutrient – signal transduction – cell projection organization – germ cell development – negative regulation of cell size – negative regulation of macroautophagy – peptidyl-threonine phosphorylation – positive regulation of actin filament polymerization – positive regulation of endothelial cell proliferation – positive regulation of lamellipodium assembly – positive regulation of peptidyl-tyrosine phosphorylation – positive regulation of protein kinase B signaling cascade – positive regulation of stress fiber assembly – positive regulation of translation – protein amino acid phosphorylation – regulation of Rac GTPase activity – regulation of carbohydrate metabolic process – regulation of carbohydrate utilization – regulation of fatty acid beta-oxidation – regulation of glycogen biosynthetic process – regulation of protein kinase activity – regulation of response to food – response to insulin stimulus – ruffle organization – G1/S transition of mitotic cell cycle – TOR signaling cascade – peptidyl-serine phosphorylation – phosphorylation – gut development – regulation of transcription, DNA-dependent

Mechanistic Target of Rapamycin (serine/threonine Kinase) ist wie folgt lokalisiert:

Golgi apparatus – TORC1 complex – TORC2 complex – cytoplasm – cytosol – endomembrane system – endoplasmic reticulum – internal side of plasma membrane – membrane – mitochondrial outer membrane – mitochondrion – phosphoinositide 3-kinase complex – dendrite – neuronal cell body – nucleus – soluble fraction – Golgi membrane – endoplasmic reticulum membrane – mTOR-FKBP12 complex

Quelle: NCBI Entrez Gene, Gene Ontology