Die folgenden Gennamen und Gensymbole werden für Antigen Lysine (K)-Specific Demethylase 1A über verschiedene Spezies hinweg verwendet:

lysine (K)-specific demethylase 1A (KDM1A), lysine (K)-specific demethylase 1 (Kdm1), amine oxidase (flavin containing) domain 2 (AOF2), lysine (K)-specific demethylase 1 (KDM1), lysine (K)-specific demethylase 1 (kdm1), lysine (K)-specific demethylase 1A (kdm1a)

Zu den weiteren Synonymen zählen:

AOF2, KDM1, LSD1, BHC110, KIAA0601, RP1-184J9.1, Aof2, Lsd1, AA408884, mKIAA0601, D4Ertd478e, 1810043O07Rik, RGD1562975, aof2, wu:fj36a05, KDM1A, DKFZp459N2450, kdm1, lsd1, xLSD1

Auf Proteinebene tauchen folgende Bezeichner für Antigen Lysine (K)-Specific Demethylase 1A auf:

lysine-specific histone demethylase 1 – lysine (K)-specific demethylase 1 – BRAF35-HDAC complex protein BHC110 – amine oxidase (flavin containing) domain 2 – FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit – lysine-specific histone demethylase 1A – neuroprotective protein 3 – lysine (K)-specific demethylase 1A

Lysine (K)-Specific Demethylase 1A erfüllt eine Reihe von Funktionen:

FAD binding – electron carrier activity – histone demethylase activity – oxidoreductase activity – promoter binding – transcription factor activity – transcription factor binding – transcription repressor activity – androgen receptor binding – chromatin binding – histone demethylase activity (H3-K4 specific) – histone demethylase activity (H3-K9 specific) – histone demethylase activity (H3-dimethyl-K4 specific) – ligand-dependent nuclear receptor transcription coactivator activity – protein binding – sequence-specific DNA binding transcription factor activity – binding – catalytic activity

Lysine (K)-Specific Demethylase 1A spielt in den folgenden Prozessen eine Rolle:

cell proliferation – chromatin modification – histone demethylation – in utero embryonic development – multicellular organismal development – negative regulation of gene-specific transcription from RNA polymerase II promoter – negative regulation of transcription factor activity – oxidation reduction – pituitary gland development – positive regulation of hormone biosynthetic process – positive regulation of transcription from RNA polymerase II promoter – regulation of transcription – negative regulation of transcription from RNA polymerase II promoter – transcription – histone H3-K4 demethylation – histone H3-K9 demethylation – regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor – metabolic process

Lysine (K)-Specific Demethylase 1A ist wie folgt lokalisiert:

nucleus – transcription factor complex

Quelle: NCBI Entrez Gene, Gene Ontology