Die folgenden Gennamen und Gensymbole werden für Antigen Janus Kinase 2 über verschiedene Spezies hinweg verwendet:

Janus kinase 2 (JAK2), Janus kinase 2 (Jak2)

Zu den weiteren Synonymen zählen:

JTK10, Fd17, C81284, AI504024, JAK2, DKFZp469G074

Auf Proteinebene tauchen folgende Bezeichner für Antigen Janus Kinase 2 auf:

Janus kinase 2 – tyrosine-protein kinase JAK2 – Janus kinase 2 (a protein tyrosine kinase) – JAK-2 – Tyrosine-protein kinase JAK2

Janus Kinase 2 erfüllt eine Reihe von Funktionen:

ATP binding – Janus kinase activity – SH2 domain binding – growth hormone receptor binding – interleukin-12 receptor binding – non-membrane spanning protein tyrosine kinase activity – nucleotide binding – receptor binding – transferase activity – acetylcholine receptor binding – insulin receptor substrate binding – kinase activity – peptide hormone receptor binding – phosphoinositide 3-kinase binding – protein binding – protein kinase activity – protein tyrosine kinase activity – histone binding – histone kinase activity (H3-Y41 specific)

Janus Kinase 2 spielt in den folgenden Prozessen eine Rolle:

JAK-STAT cascade involved in growth hormone signaling pathway – STAT protein nuclear translocation – apoptosis – cell motion – enzyme linked receptor protein signaling pathway – mesoderm development – myeloid cell differentiation – negative regulation of DNA binding – negative regulation of cell proliferation – positive regulation of growth hormone receptor signaling pathway – positive regulation of peptidyl-tyrosine phosphorylation – positive regulation of phosphoinositide 3-kinase cascade – positive regulation of tyrosine phosphorylation of Stat3 protein – positive regulation of tyrosine phosphorylation of Stat5 protein – response to antibiotic – tyrosine phosphorylation of STAT protein – G-protein coupled receptor protein signaling pathway – JAK-STAT cascade – activation of JAK2 kinase activity – activation of MAPKK activity – axon regeneration – cell differentiation – chromatin modification – cytokine-mediated signaling pathway – elevation of cytosolic calcium ion concentration – erythrocyte differentiation – hormone-mediated signaling pathway – induction of apoptosis by oxidative stress – intracellular protein kinase cascade – mineralocorticoid receptor signaling pathway – negative regulation of cell-cell adhesion – negative regulation of heart contraction – neuroprotection – peptidyl-tyrosine phosphorylation – platelet-derived growth factor receptor signaling pathway – positive regulation of DNA binding – positive regulation of apoptosis – positive regulation of cell activation – positive regulation of cell differentiation – positive regulation of cell migration – positive regulation of cell proliferation – positive regulation of inflammatory response – positive regulation of insulin secretion – positive regulation of interleukin-1 beta production – positive regulation of nitric oxide biosynthetic process – positive regulation of phosphoprotein phosphatase activity – positive regulation of protein import into nucleus, translocation – positive regulation of transcription factor activity – protein amino acid autophosphorylation – protein amino acid phosphorylation – response to hydroperoxide – response to oxidative stress – signal transduction – tyrosine phosphorylation of Stat1 protein – tyrosine phosphorylation of Stat3 protein – histone H3-Y41 phosphorylation

Janus Kinase 2 ist wie folgt lokalisiert:

caveola – cytoplasm – cytoskeleton – extrinsic to membrane – membrane – nucleus – cytosol – membrane fraction – membrane raft – nuclear matrix

Quelle: NCBI Entrez Gene, Gene Ontology