Die folgenden Gennamen und Gensymbole werden für Antigen Interleukin 6 über verschiedene Spezies hinweg verwendet:

interleukin 6 (interferon, beta 2) (IL6), interleukin 6 (Il6), interleukin 6 (IL6), interleukin-6 (il-6)

Zu den weiteren Synonymen zählen:

HGF, HSF, BSF2, IL-6, IFNB2, Il-6, ILg6, Ifnb2, IL6, il-6

Auf Proteinebene tauchen folgende Bezeichner für Antigen Interleukin 6 auf:

interleukin 6 – interleukin BSF-2 – OTTHUMP00000158544 – hybridoma growth factor – CTL differentiation factor – B cell stimulatory factor-2 – B-cell differentiation factor – interleukin-6 – interleukin HP-1 – B-cell hybridoma growth factor – IL-6 – Interleukin 6 (interferon, beta 2) – Interleukin-6

Interleukin 6 erfüllt eine Reihe von Funktionen:

cytokine activity – growth factor activity – interleukin-6 receptor binding – protein binding – receptor binding

Interleukin 6 spielt in den folgenden Prozessen eine Rolle:

acute-phase response – defense response to Gram-negative bacterium – defense response to Gram-positive bacterium – defense response to virus – endocrine pancreas development – glucagon secretion – hepatic immune response – humoral immune response – inflammatory response – interleukin-6-mediated signaling pathway – monocyte chemotaxis – negative regulation of apoptosis – negative regulation of cell proliferation – negative regulation of chemokine biosynthetic process – negative regulation of collagen biosynthetic process – neuron projection development – neutrophil apoptosis – neutrophil mediated immunity – platelet activation – positive regulation of B cell activation – positive regulation of JAK-STAT cascade – positive regulation of MAPKKK cascade – positive regulation of NF-kappaB transcription factor activity – positive regulation of T cell proliferation – positive regulation of acute inflammatory response – positive regulation of anti-apoptosis – positive regulation of chemokine production – positive regulation of gene-specific transcription – positive regulation of immunoglobulin secretion – positive regulation of interleukin-6 production – positive regulation of leukocyte chemotaxis – positive regulation of osteoblast differentiation – positive regulation of peptidyl-serine phosphorylation – positive regulation of peptidyl-tyrosine phosphorylation – positive regulation of smooth muscle cell proliferation – positive regulation of transcription from RNA polymerase II promoter – positive regulation of translation – positive regulation of tyrosine phosphorylation of Stat3 protein – regulation of angiogenesis – regulation of vascular endothelial growth factor production – response to glucocorticoid stimulus – response to peptidoglycan – branching involved in salivary gland morphogenesis – cell redox homeostasis – defense response to protozoan – epithelial cell proliferation involved in salivary gland morphogenesis – immune response – muscle cell homeostasis – negative regulation of caspase activity – negative regulation of cytokine secretion – negative regulation of gluconeogenesis – negative regulation of hormone secretion – negative regulation of muscle organ development – negative regulation of protein kinase activity – neuroprotection – positive regulation of DNA replication – positive regulation of ERK1 and ERK2 cascade – positive regulation of T-helper 2 cell differentiation – positive regulation of epithelial cell proliferation – positive regulation of gene expression – positive regulation of neuron differentiation – positive regulation of nitric oxide biosynthetic process – positive regulation of protein import into nucleus, translocation – positive regulation of transcription, DNA-dependent – positive regulation of transmission of nerve impulse – regulation of apoptosis – regulation of cell proliferation – regulation of cell shape – regulation of circadian sleep/wake cycle, non-REM sleep – aging – bone remodeling – cytokine-mediated signaling pathway – positive regulation of cell proliferation – positive regulation of transcription factor activity – response to amino acid stimulus – response to antibiotic – response to bacterium – response to caffeine – response to calcium ion – response to cold – response to cytokine stimulus – response to drug – response to electrical stimulus – response to heat – response to insulin stimulus – response to lipopolysaccharide – response to mechanical stimulus – response to nutrient levels – response to organic cyclic substance – response to protein stimulus – response to wounding – response to yeast

Interleukin 6 ist wie folgt lokalisiert:

extracellular region – extracellular space – interleukin-6 receptor complex – external side of plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology