Die folgenden Gennamen und Gensymbole werden für Antigen Integrin beta 3 über verschiedene Spezies hinweg verwendet:

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2), integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3), integrin beta 3 (Itgb3)

Zu den weiteren Synonymen zählen:

LAD, CD18, MF17, MFI7, LCAMB, LFA-1, MAC-1, CD61, GP3A, GPIIIa, INGRB3, MGC159221, MGC159223, integrin, ITGB3

Auf Proteinebene tauchen folgende Bezeichner für Antigen Integrin beta 3 auf:

integrin, beta 2 – OTTHUMP00000115279 – OTTHUMP00000115281 – OTTHUMP00000115282 – integrin beta chain, beta 2 – complement receptor C3 beta-subunit – leukocyte cell adhesion molecule CD18 – leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C – cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor) – integrin beta chain, beta 3 – platelet glycoprotein IIIa – integrin beta 3 – platelet gpIIIa – OTTMUSP00000003116 – integrin beta 3 (Cd61) – integrin, beta 3 – beta3 integrin – glycoprotein GPIIIa – integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) – integrin beta3

Integrin beta 3 erfüllt eine Reihe von Funktionen:

glycoprotein binding – protein kinase binding – receptor activity – identical protein binding – integrin binding – binding – protein binding – peptide binding – protein heterodimerization activity

Integrin beta 3 spielt in den folgenden Prozessen eine Rolle:

apoptosis – cell adhesion – cell-cell signaling – cell-matrix adhesion – inflammatory response – integrin-mediated signaling pathway – leukocyte adhesion – neutrophil chemotaxis – regulation of cell shape – regulation of peptidyl-tyrosine phosphorylation – blood coagulation – cell-substrate junction assembly – interspecies interaction between organisms – negative regulation of lipid storage – negative regulation of lipid transport – negative regulation of lipoprotein metabolic process – negative regulation of low-density lipoprotein receptor biosynthetic process – negative regulation of macrophage derived foam cell differentiation – regulation of cell migration – cellular calcium ion homeostasis – positive regulation of MAPKKK cascade – regulation of G-protein coupled receptor protein signaling pathway

Integrin beta 3 ist wie folgt lokalisiert:

cytoplasm – integral to membrane – integrin complex – plasma membrane – external side of plasma membrane – platelet alpha granule membrane – membrane – membrane fraction

Quelle: NCBI Entrez Gene, Gene Ontology