Die folgenden Gennamen und Gensymbole werden für Antigen Insulin Receptor Substrate 1 über verschiedene Spezies hinweg verwendet:

insulin receptor substrate 1 (IRS1), insulin receptor substrate 1 (Irs1), insulin receptor substrate 1 (irs1), insulin receptor substrate 1 (IRS-1), insulin receptor substrate 1 (LOC100339981)

Zu den weiteren Synonymen zählen:

HIRS-1, G972R, IRS-1, IRS1IRM, irs1, MGC75645, IRS1

Auf Proteinebene tauchen folgende Bezeichner für Antigen Insulin Receptor Substrate 1 auf:

insulin receptor substrate 1 – OTTMUSP00000017705

Insulin Receptor Substrate 1 erfüllt eine Reihe von Funktionen:

SH2 domain binding – insulin receptor binding – insulin-like growth factor receptor binding – phosphoinositide 3-kinase binding – protein binding – protein kinase C binding – signal transducer activity – transmembrane receptor protein tyrosine kinase docking protein activity – protein kinase binding – receptor activity – insulin-like growth factor receptor activity – protein domain specific binding

Insulin Receptor Substrate 1 spielt in den folgenden Prozessen eine Rolle:

glucose homeostasis – insulin-like growth factor receptor signaling pathway – mammary gland development – negative regulation of insulin receptor signaling pathway – phosphoinositide 3-kinase cascade – positive regulation of cell migration – positive regulation of fatty acid beta-oxidation – positive regulation of glucose import – positive regulation of glucose metabolic process – positive regulation of glycogen biosynthetic process – positive regulation of insulin receptor signaling pathway – positive regulation of mesenchymal cell proliferation – positive regulation of phosphoinositide 3-kinase activity – protein kinase B signaling cascade – response to peptide hormone stimulus – signal transduction – insulin secretion – protein heterooligomerization

Insulin Receptor Substrate 1 ist wie folgt lokalisiert:

caveola – cytoplasm – insulin receptor complex – microsome – nucleus – plasma membrane – cytosol

Quelle: NCBI Entrez Gene, Gene Ontology