Die folgenden Gennamen und Gensymbole werden für Antigen IkappaBalpha über verschiedene Spezies hinweg verwendet:

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)

Zu den weiteren Synonymen zählen:

IKBA, MAD-3, NFKBI

Auf Proteinebene tauchen folgende Bezeichner für Antigen IkappaBalpha auf:

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha – IkappaBalpha – nuclear factor of kappa light chain gene enhancer in B-cells

IkappaBalpha erfüllt eine Reihe von Funktionen:

NF-kappaB binding – identical protein binding – nuclear localization sequence binding – ubiquitin protein ligase binding

IkappaBalpha spielt in den folgenden Prozessen eine Rolle:

anti-apoptosis – apoptosis – cytoplasmic sequestering of NF-kappaB – interspecies interaction between organisms – lipopolysaccharide-mediated signaling pathway – negative regulation of DNA binding – negative regulation of NF-kappaB transcription factor activity – negative regulation of Notch signaling pathway – negative regulation of lipid storage – negative regulation of macrophage derived foam cell differentiation – negative regulation of myeloid cell differentiation – nucleotide-binding oligomerization domain containing 1 signaling pathway – nucleotide-binding oligomerization domain containing 2 signaling pathway – positive regulation of cellular protein metabolic process – positive regulation of cholesterol efflux – positive regulation of gene-specific transcription from RNA polymerase II promoter – protein import into nucleus, translocation – regulation of NF-kappaB import into nucleus – regulation of cell proliferation – response to exogenous dsRNA – response to lipopolysaccharide – response to muramyl dipeptide – toll-like receptor 4 signaling pathway

IkappaBalpha ist wie folgt lokalisiert:

I-kappaB/NF-kappaB complex – cytoplasm – cytosol – nucleus

Quelle: NCBI Entrez Gene, Gene Ontology