Die folgenden Gennamen und Gensymbole werden für Antigen IKK alpha/beta über verschiedene Spezies hinweg verwendet:

conserved helix-loop-helix ubiquitous kinase (CHUK), conserved helix-loop-helix ubiquitous kinase (Chuk), inhibitor of nuclear factor kappa-B kinase subunit alpha (chuk)

Zu den weiteren Synonymen zählen:

IKK1, IKKA, IKBKA, TCF16, NFKBIKA, IKK-alpha, Ikka, Chuk1, Fbx24, Fbxo24, AI256658, MGC25325, CHUK, chuk, MGC83432, DKFZp459O053

Auf Proteinebene tauchen folgende Bezeichner für Antigen IKK alpha/beta auf:

conserved helix-loop-helix ubiquitous kinase – IKK-a kinase – I-kappa-B kinase 1 – I-kappa-B kinase-alpha – IkB kinase alpha subunit – conserved helix-loop ubiquitous kinase – Nuclear factor NFkappaB inhibitor kinase alpha – inhibitor of nuclear factor kappa-B kinase subunit alpha – IKK-A – IKK alpha – I kappa B kinase 1 – OTTMUSP00000038221 – IkappaB kinase alpha – I-kappa-B kinase alpha – nuclear factor NF-kappa-B inhibitor kinase alpha – ikBKA – NFKBIKA – IKK-alpha – i kappa-B kinase alpha

IKK alpha/beta erfüllt eine Reihe von Funktionen:

ATP binding – IkappaB kinase activity – identical protein binding – nucleotide binding – transferase activity – kinase activity – protein binding – protein heterodimerization activity – protein kinase activity – protein serine/threonine kinase activity – receptor signaling protein serine/threonine kinase activity

IKK alpha/beta spielt in den folgenden Prozessen eine Rolle:

I-kappaB phosphorylation – anatomical structure morphogenesis – immune response – morphogenesis of an epithelial sheet – odontogenesis of dentine-containing tooth – osteoclast differentiation – Rho protein signal transduction – lactation – mammary gland alveolus development – mammary gland epithelial cell proliferation – phosphorylation – positive regulation of I-kappaB kinase/NF-kappaB cascade – protein amino acid phosphorylation – response to lipopolysaccharide – response to organic substance – striated muscle cell differentiation – response to acid – response to amino acid stimulus – response to drug – response to hydroperoxide – response to toxin – skeletal muscle contraction

IKK alpha/beta ist wie folgt lokalisiert:

cytoplasm – cytosol – nucleus – IkappaB kinase complex – microsome

Quelle: NCBI Entrez Gene, Gene Ontology