Die folgenden Gennamen und Gensymbole werden für Antigen Histone Deacetylase 4 über verschiedene Spezies hinweg verwendet:

histone deacetylase 4 (HDAC4), histone deacetylase 5 (Hdac5), histone deacetylase 4 (Hdac4), histone deacetylase 4 (hdac4), histone deacetylase 4 (PTRG_03699), histone deacetylase 4 (PGTG_15512), HDAC4, isoform D (HDAC4), DanaGF18710-PA (DanaHDAC4)

Zu den weiteren Synonymen zählen:

HD4, HDACA, HA6116, HDAC-A, KIAA0288, Hdac4, mHDA1, AI426555, mKIAA0600, AI047285, 4932408F19Rik, wu:fa96d08, wu:fc56f08, zgc:152701, CG1770, dHDAC4, DHDAC4, DmelCG1770, dmHDA405, GC1770, HDAC, HDAC4a, dana_GLEANR_19966, DanaGF18710, GF18710, HDAC4

Auf Proteinebene tauchen folgende Bezeichner für Antigen Histone Deacetylase 4 auf:

histone deacetylase 4 – histone deacetylase A – histone deacetylase 5 – HD5 – OTTMUSP00000002428 – OTTMUSP00000030249 – OTTMUSP00000030251 – histone deacetylase mHDA1 – HD4 – HDAC4, isoform D – CG1770-PD – HDAC4-PD – HDAC4, isoform E – CG1770-PE – HDAC4-PE – HDAC4, isoform B – CG1770-PB – HDAC4-PB – DanaGF18710-PA – DanaHDAC4-PA – GF18710-PA – HDAC4 – HDAC4-PA

Histone Deacetylase 4 erfüllt eine Reihe von Funktionen:

histone deacetylase activity – histone deacetylase binding – hydrolase activity – potassium ion binding – promoter binding – specific transcriptional repressor activity – transcription activator activity – transcription activator binding – transcription factor binding – transcription repressor binding – zinc ion binding – protein binding – transcription corepressor activity – transcription repressor activity – DNA binding – protein deacetylase activity – molecular_function – sequence-specific DNA binding

Histone Deacetylase 4 spielt in den folgenden Prozessen eine Rolle:

B cell differentiation – chromatin remodeling – histone deacetylation – inflammatory response – negative regulation of cell proliferation – negative regulation of gene-specific transcription from RNA polymerase II promoter – negative regulation of glycolysis – negative regulation of myotube differentiation – negative regulation of transcription factor activity – nervous system development – peptidyl-lysine deacetylation – positive regulation of cell proliferation – positive regulation of gene-specific transcription from RNA polymerase II promoter – positive regulation of protein sumoylation – positive regulation of transcription factor activity – regulation of protein binding – regulation of transcription – response to denervation involved in regulation of muscle adaptation – response to interleukin-1 – skeletal system development – chromatin modification – heart development – negative regulation of osteoblast differentiation – negative regulation of transcription from RNA polymerase II promoter – negative regulation of transcription, DNA-dependent – osteoblast development – regulation of skeletal muscle fiber development – regulation of striated muscle cell differentiation – response to cocaine – response to stress – transcription – regulation of cardiac muscle contraction by calcium ion signaling – response to drug – histone H3 deacetylation – histone H4 deacetylation – B cell activation – chromatin organization – negative regulation of striated muscle tissue development

Histone Deacetylase 4 ist wie folgt lokalisiert:

cytoplasm – histone deacetylase complex – nucleus – transcriptional repressor complex – cytosol – nuclear body – A band – Z disc – actomyosin – neuromuscular junction – sarcomere

Quelle: NCBI Entrez Gene, Gene Ontology