Die folgenden Gennamen und Gensymbole werden für Antigen High-Mobility Group Box 1 über verschiedene Spezies hinweg verwendet:

high-mobility group box 1 (HMGB1), high mobility group box 1 (Hmgb1), high-mobility group box 1 (hmgb1), high mobility group protein B1-like (LOC100392312)

Zu den weiteren Synonymen zählen:

HMG1, HMG3, SBP-1, DKFZp686A04236, DEF, p30, Hmg1, HMG-1, MGC103168, MGC103169, MGC117896, MGC117897, amphoterin, hmgb1, fb23c02, zgc:56110, zgc:77104, wu:fb23c02, ik:tdsubc_1a5, xx:tdsubc_1a5, MGC64255, hmg1, hmg3, sbp-1, MGC75695, HMGB1

Auf Proteinebene tauchen folgende Bezeichner für Antigen High-Mobility Group Box 1 auf:

high-mobility group box 1 – Amphoterin – OTTHUMP00000018196 – OTTHUMP00000190860 – OTTHUMP00000200117 – high mobility group box 1 – high mobility group protein 1 – Sulfoglucuronyl carbohydrate binding protein – high-mobility group (nonhistone chromosomal) protein 1 – OTTMUSP00000018031 – OTTMUSP00000018032 – OTTMUSP00000018033 – sulfoglucuronyl carbohydrate binding protein – high mobility group protein B1 – HMG-1 – high mobility group 1 protein – high mobility group protein HMG1 – non-histone protein HMG1 – High mobility group protein B1 – high mobility group protein B1-like – High mobility group protein 1

High-Mobility Group Box 1 erfüllt eine Reihe von Funktionen:

DNA bending activity – transcription factor binding – DNA binding – bent DNA binding – calcium-dependent protein kinase regulator activity – crossed form four-way junction DNA binding – cytokine activity – heparin binding – open form four-way junction DNA binding – protein kinase activator activity – chemoattractant activity – damaged DNA binding – double-stranded DNA binding – histone binding – single-stranded DNA binding

High-Mobility Group Box 1 spielt in den folgenden Prozessen eine Rolle:

DNA recombination – DNA repair – DNA unwinding during replication – anti-apoptosis – base-excision repair, DNA ligation – chromatin organization – negative regulation of RNA polymerase II transcriptional preinitiation complex assembly – regulation of transcription from RNA polymerase II promoter – signal transduction – DNA geometric change – eye development – induction of positive chemotaxis – lung development – positive regulation of cell migration – positive regulation of gene-specific transcription from RNA polymerase II promoter – positive regulation of glycogen catabolic process – positive regulation of mesenchymal cell proliferation – positive regulation of mitotic cell cycle – positive regulation of myeloid cell differentiation – positive regulation of protein amino acid phosphorylation – response to glucocorticoid stimulus – DNA topological change – V(D)J recombination – chromatin remodeling – dendritic cell chemotaxis – myeloid dendritic cell activation – response to cold

High-Mobility Group Box 1 ist wie folgt lokalisiert:

condensed chromosome – nucleolus – nucleoplasm – nucleus – chromosome – cytoplasm – extracellular space – neuron projection – soluble fraction

Quelle: NCBI Entrez Gene, Gene Ontology