Die folgenden Gennamen und Gensymbole werden für Antigen High Mobility Group Protein 1 über verschiedene Spezies hinweg verwendet:

high mobility group box 1 (Hmgb1), high-mobility group box 1 (HMGB1)

Zu den weiteren Synonymen zählen:

Hmg1, Ac2-008, MGC93598, MGC93599, HMG1

Auf Proteinebene tauchen folgende Bezeichner für Antigen High Mobility Group Protein 1 auf:

high mobility group protein B1 – HMG-1 – amphoterin – high mobility group 1 – heparin-binding protein p30 – high mobility group protein 1

High Mobility Group Protein 1 erfüllt eine Reihe von Funktionen:

5S rRNA binding – DNA bending activity – DNA binding – RAGE receptor binding – bent DNA binding – calcium-dependent protein kinase regulator activity – crossed form four-way junction DNA binding – cytokine activity – double-stranded DNA binding – four-way junction DNA binding – glycolipid binding – heparin binding – open form four-way junction DNA binding – protein binding – protein dimerization activity – protein kinase activator activity – sequence-specific DNA binding transcription factor activity – single-stranded DNA binding – transcription factor binding – transcription repressor binding – chemoattractant activity – damaged DNA binding – histone binding

High Mobility Group Protein 1 spielt in den folgenden Prozessen eine Rolle:

DNA geometric change – V(D)J recombination – actin cytoskeleton reorganization – base-excision repair, DNA ligation – cell morphogenesis – cellular response to interleukin-1 – chemotaxis – circadian rhythm – eye development – induction of positive chemotaxis – inflammatory response to antigenic stimulus – lung development – male-specific defense response to bacterium – myoblast proliferation – negative regulation of DNA replication – negative regulation of RNA polymerase II transcriptional preinitiation complex assembly – negative regulation of transcription from RNA polymerase II promoter – nervous system development – neuron projection development – positive regulation of DNA binding – positive regulation of apoptosis – positive regulation of caspase activity – positive regulation of cell death – positive regulation of cell migration – positive regulation of cell proliferation – positive regulation of gene-specific transcription from RNA polymerase II promoter – positive regulation of glycogen catabolic process – positive regulation of mesenchymal cell proliferation – positive regulation of mitotic cell cycle – positive regulation of myeloid cell apoptosis – positive regulation of myeloid cell differentiation – positive regulation of myoblast differentiation – positive regulation of neuron projection development – positive regulation of protein amino acid phosphorylation – positive regulation of smooth muscle cell migration – positive regulation of transcription from RNA polymerase II promoter – regulation of catalytic activity – regulation of inflammatory response – regulation of transcription from RNA polymerase II promoter – response to drug – response to glucocorticoid stimulus – response to glucose stimulus – response to heat – response to insulin stimulus – response to interferon-gamma – response to lipopolysaccharide – DNA recombination – DNA topological change – chromatin remodeling – dendritic cell chemotaxis – myeloid dendritic cell activation

High Mobility Group Protein 1 ist wie folgt lokalisiert:

cell surface – chromosome – condensed chromosome – cytoplasm – extracellular space – neuron projection – nucleolus – nucleoplasm – nucleus – soluble fraction – transcriptional repressor complex

Quelle: NCBI Entrez Gene, Gene Ontology