Die folgenden Gennamen und Gensymbole werden für Antigen Hematopoietically Expressed Homeobox über verschiedene Spezies hinweg verwendet:

hematopoietically expressed homeobox (Hhex), Homeobox protein PRH (Bm1_31285), Homeobox protein PRH (hhex), hematopoietically expressed homeobox (HHEX), hematopoietically expressed homeobox (hhex), hematopoietically expressed homeobox (hhex-A), hematopoietically expressed homeobox (Hex1)

Zu den weiteren Synonymen zählen:

Hex, Prh, Prhx, Hhex-rs2, hhex, HEX, PRH, HMPH, PRHX, HOX11L-PEN, hex, hhex-A, XHex, MGC69042, prh, hmph, prhx, tHex, hox11l-pen, PROBOX, HHEX

Auf Proteinebene tauchen folgende Bezeichner für Antigen Hematopoietically Expressed Homeobox auf:

hematopoietically expressed homeobox – OTTMUSP00000023363 – hematopoietically expressed homeobox, related sequence 2 – Homeobox protein PRH – hematopoietically-expressed homeobox protein HHEX – homeobox protein HEX – homeobox protein PRH – homeobox, hematopoietically expressed – proline-rich homeodomain-containing transcription factor – Hematopoietically-expressed homeobox protein hhex – homeodomain transcription factor

Hematopoietically Expressed Homeobox erfüllt eine Reihe von Funktionen:

DNA binding – sequence-specific DNA binding – transcription factor activity – transcription regulator activity – transcription repressor activity – DNA bending activity – TATA-binding protein binding – chromatin binding – eukaryotic initiation factor 4E binding – general transcriptional repressor activity – promoter binding – protein binding – protein homodimerization activity – sequence-specific DNA binding transcription factor activity – transcription factor binding – transcription repressor binding

Hematopoietically Expressed Homeobox spielt in den folgenden Prozessen eine Rolle:

Wnt receptor signaling pathway – anterior/posterior pattern formation – cell differentiation – embryonic heart tube development – embryonic organ development – endoderm development – forebrain development – interkinetic nuclear migration – liver development – multicellular organismal development – negative regulation of angiogenesis – negative regulation of gene-specific transcription from RNA polymerase II promoter – negative regulation of vascular endothelial growth factor receptor signaling pathway – organ morphogenesis – pancreas development – positive regulation of Wnt receptor signaling pathway – primary lung bud formation – regulation of cell proliferation – regulation of transcription – regulation of transcription, DNA-dependent – thyroid gland development – transcription – B cell differentiation – DNA conformation change – bile duct development – cell cycle – cell proliferation – gall bladder development – hemopoiesis – hepatic duct development – hepatoblast differentiation – hepatocyte differentiation – mRNA export from nucleus – morphogenesis of an epithelium – myeloid leukocyte differentiation – negative regulation of transcription by competitive promoter binding – negative regulation of transcription by transcription factor localization – poly(A)+ mRNA export from nucleus – positive regulation of gene-specific transcription from RNA polymerase II promoter – protein localization in nucleus – response to peptide hormone stimulus – response to wounding – vasculogenesis – determination of left/right symmetry – dorsal/ventral pattern formation – embryonic hemopoiesis – gut development – heart development – hemangioblast cell differentiation – negative regulation of transcription from RNA polymerase II promoter – positive regulation of endothelial cell differentiation – regulation of organ growth

Hematopoietically Expressed Homeobox ist wie folgt lokalisiert:

nucleus – cytoplasm – protein-DNA complex

Quelle: NCBI Entrez Gene, Gene Ontology