Die folgenden Gennamen und Gensymbole werden für Antigen Heat Shock Protein 65 über verschiedene Spezies hinweg verwendet:

heat shock 60kDa protein 1 (chaperonin) (HSPD1)

Zu den weiteren Synonymen zählen:

HLD4, CPN60, GROEL, HSP60, HSP65, SPG13, HuCHA60

Auf Proteinebene tauchen folgende Bezeichner für Antigen Heat Shock Protein 65 auf:

chaperonin – heat shock protein 65 – P60 lymphocyte protein – mitochondrial matrix protein P1 – short heat shock protein 60 Hsp60s1

Heat Shock Protein 65 erfüllt eine Reihe von Funktionen:

ATP binding – ATPase activity – DNA replication origin binding – cell surface binding – chaperone binding – lipopolysaccharide binding – nucleotide binding – p53 binding – single-stranded DNA binding – unfolded protein binding

Heat Shock Protein 65 spielt in den folgenden Prozessen eine Rolle:

'de novo' protein folding – B cell cytokine production – B cell proliferation – MyD88-dependent toll-like receptor signaling pathway – activation of caspase activity – cell death – chaperone-mediated protein complex assembly – interspecies interaction between organisms – isotype switching to IgG isotypes – negative regulation of apoptosis – positive regulation of T cell activation – positive regulation of T cell mediated immune response to tumor cell – positive regulation of apoptosis – positive regulation of interferon-alpha production – positive regulation of interferon-gamma production – positive regulation of interleukin-10 production – positive regulation of interleukin-12 production – positive regulation of interleukin-6 production – positive regulation of macrophage activation – protein maturation – protein refolding – protein stabilization – response to unfolded protein

Heat Shock Protein 65 ist wie folgt lokalisiert:

cell surface – coated pit – coated vesicle – cyclin-dependent protein kinase activating kinase holoenzyme complex – cytoplasm – cytosol – early endosome – extracellular space – lipopolysaccharide receptor complex – mitochondrial inner membrane – mitochondrial matrix – mitochondrion – plasma membrane part – secretory granule

Quelle: NCBI Entrez Gene, Gene Ontology