Die folgenden Gennamen und Gensymbole werden für Antigen Heat Shock Protein 60 über verschiedene Spezies hinweg verwendet:

heat shock protein-60 (groEL_3), heat shock 60kDa protein 1 (chaperonin) (HSPD1), heat shock protein 1 (chaperonin) (Hspd1), Heat shock protein 60 (Hsp60), heat shock protein 60 (PF10_0153), HSP60 (HEAT SHOCK PROTEIN 60); ATP binding (HSP60), heat shock protein 60 (TP04_0066), heat shock protein 60 (HSP60), heat shock protein 60 (PVX_095000), heat shock protein 60 (BBOV_IV006790), heat shock protein 60 (TGME49_047550)

Zu den weiteren Synonymen zählen:

HLD4, CPN60, GROEL, HSP60, HSP65, SPG13, HuCHA60, 60kDa, Hsp60, 12, BP5, Cpn60, Dmhsp60, G62, Hsp60A, Mmp-P1, l(1)10Ac, l(1)BP5, l(1)G8, l(1)HM21, l(1)L12, l(1)dp025, DmelCG12101, CG12101, HEAT SHOCK PROTEIN 60, HEAT SHOCK PROTEIN 60-3B, HSP60-3B, 23.m06276

Auf Proteinebene tauchen folgende Bezeichner für Antigen Heat Shock Protein 60 auf:

heat shock protein-60 – chaperonin – heat shock protein 65 – P60 lymphocyte protein – mitochondrial matrix protein P1 – short heat shock protein 60 Hsp60s1 – 60 kDa heat shock protein, mitochondrial – CPN60 – HSP-60 – HSP-65 – chaperonin 60 – 60 kDa chaperonin – OTTMUSP00000024365 – heat shock protein 60 – heat shock protein, 60 kDa – heat shock 60kDa protein 1 (chaperonin) – heat shock protein 60, isoform A – CG12101-PA – Hsp60-PA – heat shock protein 60 kDa – lethal(1)10Ac – heat shock protein 60, isoform B – CG12101-PB – Hsp60-PB – HSP60 (HEAT SHOCK PROTEIN 60); ATP binding

Heat Shock Protein 60 erfüllt eine Reihe von Funktionen:

ATP binding – ATPase activity – DNA replication origin binding – cell surface binding – chaperone binding – lipopolysaccharide binding – nucleotide binding – p53 binding – single-stranded DNA binding – unfolded protein binding – insulin binding – misfolded protein binding – protease binding – protein binding – protein complex binding – protein heterodimerization activity – ATPase activity, coupled – copper ion binding

Heat Shock Protein 60 spielt in den folgenden Prozessen eine Rolle:

'de novo' protein folding – B cell cytokine production – B cell proliferation – MyD88-dependent toll-like receptor signaling pathway – activation of caspase activity – cell death – chaperone-mediated protein complex assembly – interspecies interaction between organisms – isotype switching to IgG isotypes – negative regulation of apoptosis – positive regulation of T cell activation – positive regulation of T cell mediated immune response to tumor cell – positive regulation of apoptosis – positive regulation of interferon-alpha production – positive regulation of interferon-gamma production – positive regulation of interleukin-10 production – positive regulation of interleukin-12 production – positive regulation of interleukin-6 production – positive regulation of macrophage activation – protein maturation – protein refolding – protein stabilization – response to unfolded protein – T cell activation – anti-apoptosis – cellular protein metabolic process – chaperone mediated protein folding requiring cofactor – detection of misfolded protein – positive regulation of anti-apoptosis – positive regulation of inflammatory response – protein folding – protein targeting to mitochondrion – response to heat – response to stress – mitochondrion organization – response to cadmium ion

Heat Shock Protein 60 ist wie folgt lokalisiert:

cell surface – coated pit – coated vesicle – cyclin-dependent protein kinase activating kinase holoenzyme complex – cytoplasm – cytosol – early endosome – extracellular space – lipopolysaccharide receptor complex – mitochondrial inner membrane – mitochondrial matrix – mitochondrion – plasma membrane part – secretory granule – Golgi apparatus – intracellular membrane-bounded organelle – membrane raft – mitochondrial crista – rough endoplasmic reticulum – stored secretory granule – zymogen granule – lipid particle – cytosolic ribosome – plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology