Die folgenden Gennamen und Gensymbole werden für Antigen Heat Shock 70 KDa über verschiedene Spezies hinweg verwendet:

heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5), heat shock protein 5 (Hspa5), heat shock 70 kDa protein 5a (hspa5)

Zu den weiteren Synonymen zählen:

BIP, MIF2, GRP78, FLJ26106, Bip, Sez7, mBiP, Grp78, SEZ-7, Hsce70, AL022860, AU019543, D2Wsu17e, D2Wsu141e, hspa5a

Auf Proteinebene tauchen folgende Bezeichner für Antigen Heat Shock 70 KDa auf:

heat shock 70kDa protein 5 – Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD) – heat shock 70kD protein 5 (glucose-regulated protein, 78kD) – 78 kDa glucose-regulated protein – GRP-78 – OTTMUSP00000012896 – OTTMUSP00000012897 – heat shock 70 kDa protein 5 – glucose regulated protein, 78 kDa – immunoglobulin heavy chain-binding protein – GRP 78 – heat shock 70kD protein 5 – steroidogenesis-activator polypeptide – heat shock 70kDa protein 5 (glucose-regulated protein) – biP – heavy-chain binding protein BiP

Heat Shock 70 KDa erfüllt eine Reihe von Funktionen:

ATP binding – calcium ion binding – caspase inhibitor activity – nucleotide binding – protein binding, bridging – ribosome binding – unfolded protein binding – misfolded protein binding – protein binding – ubiquitin protein ligase binding

Heat Shock 70 KDa spielt in den folgenden Prozessen eine Rolle:

ER overload response – anti-apoptosis – cellular response to glucose starvation – negative regulation of caspase activity – activation of signaling protein activity involved in unfolded protein response – cerebellar Purkinje cell layer development – cerebellum structural organization – negative regulation of transforming growth factor beta receptor signaling pathway – positive regulation of embryonic development – positive regulation of protein ubiquitination – proteolysis involved in cellular protein catabolic process – response to stress – negative regulation of apoptosis

Heat Shock 70 KDa ist wie folgt lokalisiert:

ER-Golgi intermediate compartment – caspase complex – cell surface – endoplasmic reticulum – endoplasmic reticulum lumen – integral to endoplasmic reticulum membrane – melanosome – nucleus – perinuclear region of cytoplasm – extracellular region

Quelle: NCBI Entrez Gene, Gene Ontology