Die folgenden Gennamen und Gensymbole werden für Antigen Heat Shock 60kDa Protein 1 (Chaperonin) über verschiedene Spezies hinweg verwendet:

heat shock 60kDa protein 1 (chaperonin) (HSPD1), heat shock 60kDa protein 1 (chaperonin) (hspd1), heat shock 60kD protein 1 (chaperonin) (hspd1), Hsp60p (HSP60), chaperonin GroEL (groEL), chaperonin GroEL (hsp60), 60 kDa chaperonin (GroEL) (groEl), mitochondrial chaperonin (HSP60), heat shock protein 60 (hsp60), heat shock 60kDa protein 1 (HSPD1)

Zu den weiteren Synonymen zählen:

HSPD1, DKFZp459H2320, HLD4, CPN60, GROEL, HSP60, HSP65, SPG13, HuCHA60, hld4, cpn60, groel, hsp60, hsp65, spg13, chaperonin, cb863, fa04a05, fb22d10, fi27b05, sb:cb144, id:ibd2197, wu:fa04a05, wu:fb22d10, wu:fi04a12, wu:fi27b05, MIF4, MNA2, mopA, groL, crpA

Auf Proteinebene tauchen folgende Bezeichner für Antigen Heat Shock 60kDa Protein 1 (Chaperonin) auf:

heat shock 60kDa protein 1 (chaperonin) – chaperonin – heat shock 60 kDa protein 1 – 60 kDa heat shock protein, mitochondrial – heat shock protein 65 – P60 lymphocyte protein – mitochondrial matrix protein P1 – short heat shock protein 60 Hsp60s1 – CPN60 – HSP-60 – chaperonin 60 – 60 kDa chaperonin – heat shock protein 60 – 60 kDa heat shock protein, mitochondrial-like – nbl – hsp60 – no blastema – Hsp60p – Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated – chaperonin GroEL – 60 kDa chaperonin (GroEL) – mitochondrial chaperonin – heat shock 60kDa protein 1

Heat Shock 60kDa Protein 1 (Chaperonin) erfüllt eine Reihe von Funktionen:

ATP binding – lipopolysaccharide binding – nucleotide binding – protein binding – ATPase activity – DNA replication origin binding – cell surface binding – chaperone binding – p53 binding – single-stranded DNA binding – unfolded protein binding

Heat Shock 60kDa Protein 1 (Chaperonin) spielt in den folgenden Prozessen eine Rolle:

T cell activation – positive regulation of interferon-alpha production – positive regulation of interferon-gamma production – protein folding – 'de novo' protein folding – B cell cytokine production – B cell proliferation – MyD88-dependent toll-like receptor signaling pathway – activation of caspase activity – cell death – chaperone-mediated protein complex assembly – interspecies interaction between organisms – isotype switching to IgG isotypes – negative regulation of apoptosis – positive regulation of T cell activation – positive regulation of T cell mediated immune response to tumor cell – positive regulation of apoptosis – positive regulation of interleukin-10 production – positive regulation of interleukin-12 production – positive regulation of interleukin-6 production – positive regulation of macrophage activation – protein maturation – protein refolding – protein stabilization – response to unfolded protein – cellular protein metabolic process – fin regeneration – response to stress – tissue regeneration – organic acid metabolic process – protein import into mitochondrial intermembrane space

Heat Shock 60kDa Protein 1 (Chaperonin) ist wie folgt lokalisiert:

cytoplasm – mitochondrial inner membrane – mitochondrial matrix – mitochondrion – plasma membrane part – secretory granule – cell surface – coated pit – coated vesicle – cyclin-dependent protein kinase activating kinase holoenzyme complex – cytosol – early endosome – extracellular space – lipopolysaccharide receptor complex – stored secretory granule – mitochondrial membrane – mitochondrial nucleoid

Quelle: NCBI Entrez Gene, Gene Ontology