Die folgenden Gennamen und Gensymbole werden für Antigen HLA-DR-gamma über verschiedene Spezies hinweg verwendet:

CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74)

Zu den weiteren Synonymen zählen:

DHLAG, HLADG, Ia-GAMMA, Ii, CLIP

Auf Proteinebene tauchen folgende Bezeichner für Antigen HLA-DR-gamma auf:

CD74 antigen – HLA-DR-gamma – MHC HLA-DR gamma chain – Ia-associated invariant chain – gamma chain of class II antigens – CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) – H-2 class II histocompatibility antigen gamma chain – HLA-DR-GAMMA – dinucleotide microsatellite – ia antigen-associated invariant chain – MHC class II-associated invariant chain – class II-associated invariant chain peptide – histocompatibility: class II antigens, gamma chain of – invariant polypeptide of major histocompatibility complex, class II antigen-associated

HLA-DR-gamma erfüllt eine Reihe von Funktionen:

MHC class II protein binding – cytokine binding – identical protein binding – cytokine receptor activity – protein binding

HLA-DR-gamma spielt in den folgenden Prozessen eine Rolle:

T cell selection – antigen processing and presentation of endogenous antigen – cell proliferation – immune response – immunoglobulin mediated immune response – intracellular protein transport – negative regulation of apoptosis – prostaglandin biosynthetic process – protein complex assembly – regulation of macrophage activation – signal transduction – activation of MAPK activity – antigen processing and presentation – antigen processing and presentation of exogenous peptide antigen via MHC class II – chaperone mediated protein folding requiring cofactor – defense response – negative regulation of DNA damage response, signal transduction by p53 class mediator – negative regulation of T cell differentiation – negative thymic T cell selection – positive regulation of ERK1 and ERK2 cascade – positive regulation of T cell differentiation – positive regulation of cytokine-mediated signaling pathway – positive regulation of peptidyl-tyrosine phosphorylation – positive thymic T cell selection

HLA-DR-gamma ist wie folgt lokalisiert:

integral to membrane – intracellular – membrane – Golgi apparatus – endoplasmic reticulum – external side of plasma membrane – integral to plasma membrane – late endosome – lysosome – multivesicular body – plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology