Die folgenden Gennamen und Gensymbole werden für Antigen H-Calreticulin über verschiedene Spezies hinweg verwendet:

calreticulin (CALR), calreticulin (Calr), calreticulin (calr), Calreticulin (Crc), calreticulin (crc), calreticulin (Crt), calreticulin (LmjF31.2600), calreticulin (Crc), calreticulin (crt)

Zu den weiteren Synonymen zählen:

RO, CRT, SSA, cC1qR, FLJ26680, Calregulin, zgc:85636, Clr, anon-EST:Liang-2.11, anon-EST:Liang-2.17, anon-EST:fe3D7, clone 2.11, clone 2.17, eth, potp, DmelCG9429, CG9429, crc, MGC52637, crt, ssa, cc1qr, MGC69541, CALR, Crt, NV19007

Auf Proteinebene tauchen folgende Bezeichner für Antigen H-Calreticulin auf:

calreticulin – autoantigen Ro – Sicca syndrome antigen A (autoantigen Ro; calreticulin) – CRP55 – ERp60 – HACBP – OTTMUSP00000025211 – endoplasmic reticulum resident protein 60 – CG9429-PA – Crc-PA – pot pourri – potpourri – anon-fast-evolving-3D7 – CABP3 – CALBP – calregulin – calcium-binding protein 3 – ER-resident chaperone calreticulin

H-Calreticulin erfüllt eine Reihe von Funktionen:

DNA binding – androgen receptor binding – calcium ion binding – chaperone binding – complement component C1q binding – integrin binding – mRNA binding – sugar binding – transcription repressor activity – unfolded protein binding – zinc ion binding – hormone binding – iron ion binding – metal ion binding – peptide binding – protein binding – ubiquitin protein ligase binding

H-Calreticulin spielt in den folgenden Prozessen eine Rolle:

cell cycle arrest – cortical actin cytoskeleton organization – glucocorticoid receptor signaling pathway – negative regulation of neuron differentiation – negative regulation of retinoic acid receptor signaling pathway – negative regulation of steroid hormone receptor signaling pathway – negative regulation of transcription from RNA polymerase II promoter – negative regulation of translation – peptide antigen assembly with MHC class I protein complex – positive regulation of DNA replication – positive regulation of cell cycle – positive regulation of cell proliferation – positive regulation of phagocytosis – protein export from nucleus – protein maturation by protein folding – protein stabilization – regulation of apoptosis – regulation of meiosis – regulation of transcription, DNA-dependent – senescence – sequestering of calcium ion – protein folding – brain morphogenesis – central nervous system development – locomotion involved in locomotory behavior – olfactory behavior – peripheral nervous system development – startle response – cardiac muscle cell differentiation – cellular response to lithium ion – cellular response to organic substance – response to drug – response to estradiol stimulus – response to organic substance – response to testosterone stimulus – spermatogenesis

H-Calreticulin ist wie folgt lokalisiert:

MHC class I peptide loading complex – cytoplasm – cytosol – endoplasmic reticulum – endoplasmic reticulum lumen – external side of plasma membrane – extracellular region – extracellular space – microsome – nucleus – perinuclear region of cytoplasm – polysome – proteinaceous extracellular matrix – Golgi apparatus – acrosomal vesicle – cell surface – extracellular matrix – soluble fraction – lipid particle – sarcoplasmic reticulum

Quelle: NCBI Entrez Gene, Gene Ontology