Die folgenden Gennamen und Gensymbole werden für Antigen Forkhead Box P3 über verschiedene Spezies hinweg verwendet:

forkhead box A1 (FOXA1), forkhead box P3 (Foxp3), forkhead box P3 (FOXP3), forkhead box P3 (foxp3), forkhead box P3 (LOC100348270), transcription factor foxp3 (foxp3)

Zu den weiteren Synonymen zählen:

HNF3A, TCF3A, MGC33105, sf, JM2, scurfin, AIID, IPEX, PIDX, XPID, DIETER, MGC141961, MGC141963, RGD1562112, FOXP3, foxp3

Auf Proteinebene tauchen folgende Bezeichner für Antigen Forkhead Box P3 auf:

forkhead box A1 – hepatocyte nuclear factor 3, alpha – forkhead box P3 – scurfy – OTTMUSP00000017952 – OTTMUSP00000017961 – OTTMUSP00000017962 – scurfin – FOXP3delta7 – immunodeficiency, polyendocrinopathy, enteropathy, X-linked – immune dysregulation, polyendocrinopathy, enteropathy, X-linked – forkhead box protein P3 – forkhead/winged helix transcription factor 3 – regulatory protein Foxp3 – forkhead box protein P3-like – transcription factor foxp3

Forkhead Box P3 erfüllt eine Reihe von Funktionen:

sequence-specific DNA binding – transcription factor activity – DNA binding – RNA polymerase II transcription factor activity, enhancer binding – metal ion binding – protein binding – protein homodimerization activity – specific RNA polymerase II transcription factor activity – specific transcriptional repressor activity – transcription activator activity – transcription corepressor activity – transcription repressor activity – zinc ion binding – NF-kappaB binding – NFAT protein binding – general transcriptional repressor activity – histone acetyltransferase binding – histone deacetylase binding – molecular_function – sequence-specific DNA binding transcription factor activity

Forkhead Box P3 spielt in den folgenden Prozessen eine Rolle:

branching morphogenesis of a tube – epithelial cell differentiation – epithelial cell maturation – glucose homeostasis – hormone metabolic process – lung development – neuron fate specification – positive regulation of neuron differentiation – positive regulation of transcription from RNA polymerase II promoter – prostate gland development – regulation of transcription, DNA-dependent – B cell homeostasis – CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation – T cell activation – T cell mediated immunity – T cell receptor signaling pathway – cytokine production – myeloid cell homeostasis – negative regulation of T cell proliferation – negative regulation of chronic inflammatory response – negative regulation of histone acetylation – negative regulation of inflammatory response – negative regulation of interferon-gamma biosynthetic process – negative regulation of interferon-gamma production – negative regulation of interleukin-10 production – negative regulation of interleukin-2 biosynthetic process – negative regulation of interleukin-2 production – negative regulation of interleukin-4 production – negative regulation of interleukin-5 production – negative regulation of interleukin-6 production – negative regulation of isotype switching to IgE isotypes – negative regulation of lymphocyte proliferation – negative regulation of transcription from RNA polymerase II promoter – negative regulation of transcription, DNA-dependent – negative regulation of tumor necrosis factor production – positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation – positive regulation of T cell anergy – positive regulation of T cell tolerance induction – positive regulation of histone acetylation – positive regulation of immature T cell proliferation in the thymus – positive regulation of peripheral T cell tolerance induction – positive regulation of regulatory T cell differentiation – positive regulation of transforming growth factor-beta1 production – regulation of immunoglobulin production – regulation of isotype switching to IgG isotypes – regulation of transcription – regulatory T cell differentiation – tolerance induction – tolerance induction to self antigen – transcription – T cell homeostasis – chromatin remodeling – negative regulation of CREB transcription factor activity – negative regulation of NF-kappaB transcription factor activity – negative regulation of T cell cytokine production – negative regulation of activated T cell proliferation – negative regulation of cell proliferation – negative regulation of cytokine secretion – negative regulation of histone deacetylation – negative regulation of immune response – positive regulation of gene-specific transcription from RNA polymerase II promoter – positive regulation of transcription – biological_process – negative regulation of cytokine biosynthetic process – negative regulation of transcription factor activity

Forkhead Box P3 ist wie folgt lokalisiert:

nucleus – cytoplasm – intracellular – protein complex – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology