Die folgenden Gennamen und Gensymbole werden für Antigen Focal Adhesion Kinase über verschiedene Spezies hinweg verwendet:

focal adhesion kinase pp125FAK (Ptk2), PTK2 protein tyrosine kinase 2 (PTK2), PTK2 protein tyrosine kinase 2 (Ptk2), protein tyrosine kinase 2.1 (ptk2.1), Fak-like tyrosine kinase (PR2), Focal Adhesion Kinase (Fak56D)

Zu den weiteren Synonymen zählen:

Ptk2, FAK, PTK2, FADK, FRNK, Fadk, KIAA4203, mKIAA4203, fak, ptk2, fak1a, MGC66114, zgc:66114, wu:fa18c04, DPR2, DRODPR2, DmHD-11, HD-11, PR2/ACK, Rp2, dACK, DmelCG3969, CG3969, CT28129, DFAK, DFak56, DmFAK, Fak56, DmelCG10023, CG10023

Auf Proteinebene tauchen folgende Bezeichner für Antigen Focal Adhesion Kinase auf:

focal adhesion kinase pp125FAK – PTK2 protein tyrosine kinase 2 – focal adhesion kinase – protein-tyrosine kinase – protein tyrosine kinase 2.1 – Fak-like tyrosine kinase, isoform A – CG3969-PA – PR2-PA – Fak-like tyrosine kinase, isoform B – CG3969-PB – PR2-PB – focal adhesion kinase, isoform D – CG10023-PD – Fak56D-PD – focal adhesion kinase homolog – focal adhesion kinase, isoform A – CG10023-PA – Fak56D-PA – focal adhesion kinase, isoform B – CG10023-PB – Fak56D-PB – focal adhesion kinase, isoform C – CG10023-PC – Fak56D-PC – focal adhesion kinase, isoform E – CG10023-PE – Fak56D-PE

Focal Adhesion Kinase erfüllt eine Reihe von Funktionen:

kinase activity – ATP binding – non-membrane spanning protein tyrosine kinase activity – nucleotide binding – protein binding – protein kinase activity – protein tyrosine kinase activity – signal transducer activity – transferase activity

Focal Adhesion Kinase spielt in den folgenden Prozessen eine Rolle:

cytoskeleton – angiogenesis – blood vessel development – cell motion – central nervous system neuron axonogenesis – endothelial cell migration – establishment of nucleus localization – extracellular matrix organization – integrin-mediated signaling pathway – microtubule cytoskeleton organization – negative regulation of axonogenesis – negative regulation of organ growth – negative regulation of synaptogenesis – neuron migration – protein amino acid autophosphorylation – protein amino acid phosphorylation – signal complex assembly – vasculogenesis – autophagic cell death – salivary gland cell autophagic cell death – cytoskeletal anchoring at plasma membrane – regulation of cell shape

Focal Adhesion Kinase ist wie folgt lokalisiert:

apical plasma membrane – cell junction – cytoskeleton – cytosol – focal adhesion – lamellipodium – membrane – plasma membrane – internal side of plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology