Die folgenden Gennamen und Gensymbole werden für Antigen FK506 Binding Protein 1B, 12.6 KDa über verschiedene Spezies hinweg verwendet:

FK506 binding protein 1B, 12.6 kDa (FKBP1B), FK506 binding protein 1b (Fkbp1b), FK506 binding protein 1B, 12.6 kDa (fkbp1b), FK506 binding protein 1A, 12kDa (FKBP1A), FK506 binding protein 1B, 12.6 kDa (LOC100230320)

Zu den weiteren Synonymen zählen:

OTK4, FKBP1L, PKBP1L, PPIase, FKBP12.6, MGC68829, FKBP1B, FKBP1A, DKFZp459K1429

Auf Proteinebene tauchen folgende Bezeichner für Antigen FK506 Binding Protein 1B, 12.6 KDa auf:

FK506 binding protein 1B, 12.6 kDa – rotamase – calstabin 2 – immunophilin FKBP12.6 – FK506-binding protein 12.6 – FK506-binding protein 1-like – peptidyl-prolyl cis-trans isomerase – FK506 binding protein 12.6 – calstabin2 – FK506 binding protein 1A, 12kDa – FK506-binding protein 1A – PPIase 1B – Rotamase 1B – 12.6 kDa FKBP – Immunophilin FKBP12.6 – peptidyl-prolyl cis-trans isomerase 1B – peptidyl-prolyl cis-trans isomerase; PPIase

FK506 Binding Protein 1B, 12.6 KDa erfüllt eine Reihe von Funktionen:

FK506 binding – isomerase activity – peptidyl-prolyl cis-trans isomerase activity – receptor binding – ryanodine-sensitive calcium-release channel activity – protein binding – drug binding

FK506 Binding Protein 1B, 12.6 KDa spielt in den folgenden Prozessen eine Rolle:

'de novo' protein folding – muscle contraction – negative regulation of heart rate – negative regulation of protein phosphatase type 2B activity – protein maturation by protein folding – protein refolding – regulation of calcium ion transport via store-operated calcium channel activity – regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion – regulation of ryanodine-sensitive calcium-release channel activity – response to redox state – T cell proliferation – elevation of cytosolic calcium ion concentration – insulin secretion – neuronal action potential propagation – protein folding – regulation of heart rate – release of sequestered calcium ion into cytosol – release of sequestered calcium ion into cytosol by sarcoplasmic reticulum – response to glucose stimulus – response to hydrogen peroxide – response to organic substance – response to vitamin E – smooth muscle contraction – cytokine-mediated signaling pathway – negative regulation of protein amino acid phosphorylation – response to caffeine

FK506 Binding Protein 1B, 12.6 KDa ist wie folgt lokalisiert:

calcium channel complex – cytoplasm – cytosol – microsome – sarcoplasmic reticulum membrane – membrane fraction

Quelle: NCBI Entrez Gene, Gene Ontology