Die folgenden Gennamen und Gensymbole werden für Antigen Epidermal Growth Factor Receptor über verschiedene Spezies hinweg verwendet:

epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR), epidermal growth factor receptor (Egfr), Epidermal growth factor receptor (Egfr), epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (egfra), epidermal growth factor receptor (EGFR), epidermal growth factor receptor (egfr1), epidermal growth factor receptor (AaeL_AAEL004319)

Zu den weiteren Synonymen zählen:

ERBB, HER1, mENA, ERBB1, PIG61, Wa5, wa2, Erbb, Errp, wa-2, AI552599, 9030024J15Rik, ErbB-1, C-erb, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DmHD-33, EFG-R, EGF-R, EGFR, EK2-6, Egf, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, HD-33, Torpedo/DER, Torpedo/Egfr, c-erbB, d-egf-r, dEGFR1, flb, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57EFa, l(2)57Ea, pnt, top, top/DER, top/flb, DmelCG10079, CG10079, egfr, EGFR12, EGFR15, egfr1, Erbb2

Auf Proteinebene tauchen folgende Bezeichner für Antigen Epidermal Growth Factor Receptor auf:

epidermal growth factor receptor – cell growth inhibiting protein 40 – cell proliferation-inducing protein 61 – avian erythroblastic leukemia viral (v-erb-b) oncogene homolog – waved 2 – OTTMUSP00000005385 – OTTMUSP00000005386 – EGFR-related peptide – avian erythroblastic leukemia viral (v-erbB) oncogene homolog – Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) – epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) – epidermal growth factor receptor, isoform A – CG10079-PA – Egfr-PA – ellipse torpedo – ellipse – torpedo/DER – EGF-receptor – torpedo – Egf receptor – drosophila epidermal growth factor receptor homologue – faint little ball – DER-Ellipse – epidermal growth factor receptor, isoform B – CG10079-PB – Egfr-PB – erbb1a – egf receptor – epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Epidermal Growth Factor Receptor erfüllt eine Reihe von Funktionen:

ATP binding – MAP/ERK kinase kinase activity – actin filament binding – double-stranded DNA binding – epidermal growth factor receptor activity – identical protein binding – nitric-oxide synthase regulator activity – nucleotide binding – protein heterodimerization activity – protein phosphatase binding – transferase activity – transmembrane receptor activity – epidermal growth factor binding – kinase activity – protein binding – protein kinase activity – protein tyrosine kinase activity – receptor activity – receptor signaling protein tyrosine kinase activity – signal transducer activity – transmembrane receptor protein tyrosine kinase activity – gurken receptor activity – protein domain specific binding

Epidermal Growth Factor Receptor spielt in den folgenden Prozessen eine Rolle:

activation of phospholipase A2 activity by calcium-mediated signaling – activation of phospholipase C activity – cell morphogenesis – cell surface receptor linked signal transduction – cell-cell adhesion – epidermal growth factor receptor signaling pathway – ossification – positive regulation of MAP kinase activity – positive regulation of cell migration – positive regulation of cyclin-dependent protein kinase activity during G1/S – positive regulation of epithelial cell proliferation – positive regulation of nitric oxide biosynthetic process – positive regulation of phosphorylation – protein amino acid autophosphorylation – protein insertion into membrane – regulation of nitric-oxide synthase activity – regulation of peptidyl-tyrosine phosphorylation – response to UV-A – response to stress – salivary gland morphogenesis – activation of MAPKK activity – astrocyte activation – cell surface receptor linked signaling pathway – cerebral cortex cell migration – digestive tract morphogenesis – embryonic placenta development – epidermis development – hair follicle development – intracellular protein kinase cascade – morphogenesis of an epithelial fold – negative regulation of apoptosis – negative regulation of mitotic cell cycle – neuron projection morphogenesis – ovulation cycle – positive regulation of cell proliferation – positive regulation of smooth muscle cell proliferation – positive regulation of synaptic transmission, glutamatergic – protein amino acid phosphorylation – regulation of cell proliferation – response to calcium ion – signal transduction – translation – transmembrane receptor protein tyrosine kinase signaling pathway – circadian rhythm – positive regulation of catenin protein nuclear translocation – positive regulation of cyclin-dependent protein kinase activity involved in G1/S – positive regulation of protein kinase B signaling cascade – response to lipid – response to osmotic stress – response to oxidative stress – tongue development – G2/M transition of mitotic cell cycle – Malpighian tubule morphogenesis – R7 cell differentiation – antennal development – anterior/posterior pattern formation – anti-apoptosis – behavioral response to ethanol – blastoderm segmentation – border follicle cell migration – brain development – branched duct epithelial cell fate determination, open tracheal system – cell fate commitment – cell fate determination – cell projection assembly – chorion-containing eggshell pattern formation – compound eye cone cell fate commitment – compound eye development – compound eye morphogenesis – compound eye photoreceptor cell differentiation – compound eye photoreceptor fate commitment – determination of genital disc primordium – dorsal appendage formation – dorsal closure – dorsal/ventral axis specification – dorsal/ventral pattern formation – embryonic axis specification – embryonic pattern specification – establishment or maintenance of apical/basal cell polarity – eye development – eye-antennal disc morphogenesis – female germ-line cyst encapsulation – gastrulation – germ-band shortening – germ-line stem cell maintenance – gurken receptor signaling pathway – haltere development – imaginal disc development – imaginal disc pattern formation – imaginal disc-derived wing morphogenesis – imaginal disc-derived wing vein morphogenesis – imaginal disc-derived wing vein specification – leg disc proximal/distal pattern formation – maintenance of epithelial integrity, open tracheal system – male germ-line cyst encapsulation – maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded – morphogenesis of an epithelium – morphogenesis of follicular epithelium – muscle attachment – muscle cell fate specification – negative regulation of S phase of mitotic cell cycle – negative regulation of compound eye retinal cell programmed cell death – neurogenesis – notum cell fate specification – notum development – oenocyte differentiation – ommatidial rotation – oocyte anterior/posterior axis specification – oocyte axis specification – oocyte dorsal/ventral axis specification – oogenesis – open tracheal system development – peripheral nervous system development – progression of morphogenetic furrow during compound eye morphogenesis – regulation of R8 cell spacing in compound eye – regulation of hemocyte differentiation – regulation of mitotic cell cycle – sac formation, open tracheal system – salivary gland development – second mitotic wave during compound eye morphogenesis – segment polarity determination – spiracle morphogenesis, open tracheal system – stomatogastric nervous system development – wing and notum subfield formation – wing disc morphogenesis – wing disc proximal/distal pattern formation

Epidermal Growth Factor Receptor ist wie folgt lokalisiert:

AP-2 adaptor complex – Shc-EGFR complex – basolateral plasma membrane – cytoplasm – endocytic vesicle – endosome – extracellular region – extracellular space – integral to membrane – intracellular – nucleus – plasma membrane – apical plasma membrane – membrane – integral to plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology

anti-Epidermal Growth Factor Receptor (EGFR) Antikörper (ABIN197682) zitiert in Journal of orthopaedic research : official publication of the Orthopaedic Research Society

anti-Epidermal Growth Factor Receptor (EGFR) Antikörper (ABIN197682) zitiert in The Annals of thoracic surgery

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