Die folgenden Gennamen und Gensymbole werden für Antigen CBP/P300 über verschiedene Spezies hinweg verwendet:

CREB binding protein (Crebbp), nejire (nej)

Zu den weiteren Synonymen zählen:

CBP, KAT3A, AW558298, CBP/p300, p300/CBP, CBP_, Crbp, anon-WO0147981.11, anon-WO03040301.89, dCBP, dmCBP, nej CBP, p300, DmelCG15319, CG15319

Auf Proteinebene tauchen folgende Bezeichner für Antigen CBP/P300 auf:

CREB-binding protein – nejire – CG15319-PB – nej-PB – drosophila CREB-binding protein – CREB binding protein

CBP/P300 erfüllt eine Reihe von Funktionen:

DNA binding – SMAD binding – acetyltransferase activity – chromatin binding – histone acetyltransferase activity – metal ion binding – peroxisome proliferator activated receptor binding – protein binding – sequence-specific DNA binding transcription factor activity – transcription activator activity – transcription coactivator activity – transcription cofactor activity – transcription factor binding – transferase activity – zinc ion binding – cAMP response element binding protein binding

CBP/P300 spielt in den folgenden Prozessen eine Rolle:

cell proliferation – germ-line stem cell maintenance – histone acetylation – positive regulation of transcription – positive regulation of transcription factor activity – positive regulation of transcription from RNA polymerase II promoter – positive regulation of transcription, DNA-dependent – regulation of S phase – regulation of transcription – regulation of transcription, DNA-dependent – transcription – R3/R4 cell fate commitment – R7 cell differentiation – Wnt receptor signaling pathway – circadian regulation of gene expression – compound eye morphogenesis – hemopoiesis – locomotor rhythm – neurotransmitter secretion – regulation of mitosis – smoothened signaling pathway – synapse assembly

CBP/P300 ist wie folgt lokalisiert:

PML body – histone acetyltransferase complex – nucleus – outer kinetochore of condensed chromosome – protein complex – transcription factor complex

Quelle: NCBI Entrez Gene, Gene Ontology