Die folgenden Gennamen und Gensymbole werden für Antigen Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) über verschiedene Spezies hinweg verwendet:

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), cyclin-dependent kinase inhibitor 2A (Cdkn2a), cyclin-dependent kinase inhibitor 2B (melanoma, p16, inhibits CDK4) (CDKN2B), cyclin-dependent kinase inhibitor 2A (CDKN2A), cyclin-dependent kinase inhibitor 2A (LOC100340625)

Zu den weiteren Synonymen zählen:

ARF, MLM, p14, p16, p19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4a, p14ARF, p19Arf, p16INK4, p16INK4a, Arf, Pctr1, p19ARF, p19, ARF-INK4a, INK4a-ARF, Ink4a/Arf, p16(INK4a), INK4A, p16Cdkn2a, CDKN2A, p16-INK4a, p16CDKN2A

Auf Proteinebene tauchen folgende Bezeichner für Antigen Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) auf:

cyclin-dependent kinase inhibitor 2A – OTTHUMP00000021148 – CDK4 inhibitor p16-INK4 – multiple tumor suppressor 1 – cell cycle negative regulator beta – cyclin-dependent kinase inhibitor p16 – OTTMUSP00000008143 – mitochondrial smARF – cyclin-dependent kinase inhibitor protein – cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4) – CDK4I – p16-INK4 – p16-INK4a – cell cycle inhibitor – cell cycle regulator – cyclin-dependent kinase 4 inhibitor A – cyclin-dependent kinase inhibitor 2a p19Arf – cyclin-dependent kinase inhibitor 2a p16Ink4a – cyclin-dependent kinase inhibitor 2A, isoform 1 – cyclin-dependent kinase inhibitor 2A, isoform 2 – Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4) – cyclin-dependent kinase inhibitor 2B – p15INK4b tumor suppressor – cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) – cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) – ARF tumor suppressor – tumor suppressor CDKN2A – alternate product p19ARF – alternative reading frame p19

Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) erfüllt eine Reihe von Funktionen:

DNA binding – NF-kappaB binding – cyclin-dependent protein kinase inhibitor activity – protein binding – protein kinase binding – transcription factor activity – ubiquitin-protein ligase inhibitor activity – kinase activity

Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) spielt in den folgenden Prozessen eine Rolle:

DNA fragmentation involved in apoptosis – G1/S transition of mitotic cell cycle – activation of caspase activity – apoptotic mitochondrial changes – cell aging – cell cycle – cell cycle arrest – cell cycle checkpoint – epidermis development – induction of apoptosis – negative regulation of B cell proliferation – negative regulation of NF-kappaB transcription factor activity – negative regulation of cell growth – negative regulation of cell proliferation – negative regulation of cell-matrix adhesion – negative regulation of cyclin-dependent protein kinase activity – negative regulation of immature T cell proliferation in the thymus – negative regulation of phosphorylation – negative regulation of protein kinase activity – negative regulation of ubiquitin-protein ligase activity – rRNA processing – regulation of G2/M transition of mitotic cell cycle – regulation of gene expression – regulation of nucleocytoplasmic transport – regulation of protein stability – regulation of transcription – regulation of transcription, DNA-dependent – senescence – somatic stem cell division – aging – apoptosis – negative regulation of cell cycle – negative regulation of mammary gland epithelial cell proliferation – positive regulation of DNA damage response, signal transduction by p53 class mediator – positive regulation of apoptosis involved in mammary gland involution – rRNA transcription – regulation of cyclin-dependent protein kinase activity – transcription – response to drug – response to organic cyclic substance – response to organic nitrogen – response to organic substance

Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) ist wie folgt lokalisiert:

cytoplasm – nucleolus – nucleoplasm – nucleus – granular component

Quelle: NCBI Entrez Gene, Gene Ontology