Die folgenden Gennamen und Gensymbole werden für Antigen Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) über verschiedene Spezies hinweg verwendet:

cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a), cyclin-dependent kinase inhibitor 1A (Cdkn1a), cyclin-dependent kinase inhibitor 1A (p21, Cip1) (cdkn1a), cyclin-dependent kinase inhibitor 1 (cki1), cyclin-dependent kinase inhibitor 1A (cdkn1a), cyclin-dependent kinase inhibitor 1A (LOC100348489), cyclin-dependent kinase inhibitor 1A (CDKN1A)

Zu den weiteren Synonymen zählen:

P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1, CDKI, Waf1, mda6, Cdkn1, p21WAF, p21Cip1, Cip1, CDKN1A, p21, cip1, p16Xic2, sdi1, waf1, cap20, cdkn1, mda-6, p21cip1, si:ch1073-48m5.2

Auf Proteinebene tauchen folgende Bezeichner für Antigen Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) auf:

cyclin-dependent kinase inhibitor 1A – p21Cip1/Waf1 – OTTHUMP00000016298 – DNA synthesis inhibitor – CDK-interaction protein 1 – wild-type p53-activated fragment 1 – melanoma differentiation associated protein 6 – cyclin-dependent kinase inhibitor 1 – p21 – OTTMUSP00000041698 – CDK-interacting protein 1 – melanoma differentiation-associated protein – cyclin-dependent kinase inhibitor 1A (P21) – cyclin-dependent kinase inhibitor 1A (p21, Cip1) – cyclin dependent kinase inhibitor p16Xic2 – p21 – cip1 – waf1 – p21/WAF1

Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) erfüllt eine Reihe von Funktionen:

cyclin binding – cyclin-dependent protein kinase inhibitor activity – metal ion binding – protein kinase inhibitor activity – zinc ion binding – kinase activity – protein binding – protein complex binding

Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) spielt in den folgenden Prozessen eine Rolle:

G1/S transition of mitotic cell cycle – G2/M transition of mitotic cell cycle – cell cycle arrest – cellular response to extracellular stimulus – induction of apoptosis by intracellular signals – negative regulation of apoptosis – negative regulation of cell growth – negative regulation of cell proliferation – negative regulation of cyclin-dependent protein kinase activity – negative regulation of phosphorylation – positive regulation of B cell proliferation – positive regulation of fibroblast proliferation – positive regulation of programmed cell death – response to DNA damage stimulus – response to UV – cell cycle – positive regulation of anti-apoptosis – regulation of cell cycle – DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest – Ras protein signal transduction – organ regeneration – response to arsenic – response to corticosterone stimulus – response to drug – response to glucocorticoid stimulus – response to hyperoxia – response to organic cyclic substance – response to organic nitrogen – response to organic substance – response to toxin

Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) ist wie folgt lokalisiert:

cyclin-dependent protein kinase holoenzyme complex – cytoplasm – cytosol – nucleoplasm – nucleus – PCNA-p21 complex

Quelle: NCBI Entrez Gene, Gene Ontology