Die folgenden Gennamen und Gensymbole werden für Antigen Chemokine (C-C Motif) Ligand 2 über verschiedene Spezies hinweg verwendet:

chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 2 (Ccl2), small inducible cytokine A24 (LOC100354652)

Zu den weiteren Synonymen zählen:

HC11, MCAF, MCP1, MCP-1, SCYA2, GDCF-2, SMC-CF, HSMCR30, MGC9434, JE, Scya2, Sigje, AI323594, CCL2, DKFZp469C111

Auf Proteinebene tauchen folgende Bezeichner für Antigen Chemokine (C-C Motif) Ligand 2 auf:

small inducible cytokine A2 – monocyte secretory protein JE – monocyte chemoattractant protein-1 – monocyte chemotactic and activating factor – small inducible cytokine subfamily A (Cys-Cys), member 2 – small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je) – C-C motif chemokine 2 – OTTMUSP00000000786 – small-inducible cytokine A2 – monocyte chemotactic protein 1 – monocyte chemoattractant protein 1 – platelet-derived growth factor-inducible protein JE – small inducible gene JE – immediate-early serum-responsive JE protein – immediate-early serum-responsive protein JE – chemokine (C-C motif) ligand 2 – small inducible cytokine A24

Chemokine (C-C Motif) Ligand 2 erfüllt eine Reihe von Funktionen:

CCR2 chemokine receptor binding – G-protein-coupled receptor binding – chemokine activity – protein kinase activity – signal transducer activity – cytokine activity – heparin binding – protein binding

Chemokine (C-C Motif) Ligand 2 spielt in den folgenden Prozessen eine Rolle:

G-protein signaling, coupled to cyclic nucleotide second messenger – JAK-STAT cascade – anti-apoptosis – cell adhesion – cellular calcium ion homeostasis – chemotaxis – cytokine-mediated signaling pathway – humoral immune response – inflammatory response – macrophage chemotaxis – monocyte chemotaxis – organ morphogenesis – positive regulation of endothelial cell proliferation – protein amino acid phosphorylation – response to bacterium – transforming growth factor beta receptor signaling pathway – vascular endothelial growth factor receptor signaling pathway – viral genome replication – chemokine-mediated signaling pathway – immune response – lymphocyte chemotaxis – negative regulation of angiogenesis – neutrophil chemotaxis – positive regulation of immune complex clearance by monocytes and macrophages – positive regulation of macrophage chemotaxis – positive regulation of synaptic transmission – regulation of vascular endothelial growth factor production – response to heat – chemokinesis – maternal process involved in parturition – organ regeneration – response to activity – response to amino acid stimulus – response to antibiotic – response to drug – response to ethanol – response to gamma radiation – response to glucocorticoid stimulus – response to hypoxia – response to lipopolysaccharide – response to mechanical stimulus – response to progesterone stimulus – response to vitamin B3

Chemokine (C-C Motif) Ligand 2 ist wie folgt lokalisiert:

cell soma – cytoplasm – extracellular region – extracellular space – neuronal cell body

Quelle: NCBI Entrez Gene, Gene Ontology