Die folgenden Gennamen und Gensymbole werden für Antigen Caspase 8, Apoptosis-Related Cysteine Peptidase über verschiedene Spezies hinweg verwendet:

caspase 8, apoptosis-related cysteine peptidase (CASP8), caspase 8 (Casp8), caspase 8, apoptosis-related cysteine peptidase (casp8), caspase-8 (casp8-A), death related ced-3/Nedd2-like protein (Dredd), caspase-8 (AaeL_AAEL014148), caspase-8 (casp8), caspase 8 (LOC100222284)

Zu den weiteren Synonymen zählen:

CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8, FLJ17672, MGC78473, Mch5, Caspase-8, MGC92075, caspase-8, zgc:92075, casp8-A, xCaspase-8, CASP8, casp8, DKFZp469A1428

Auf Proteinebene tauchen folgende Bezeichner für Antigen Caspase 8, Apoptosis-Related Cysteine Peptidase auf:

caspase 8 – OTTHUMP00000163720 – MACH-alpha-1/2/3 protein – MACH-beta-1/2/3/4 protein – FADD-homologous ICE/CED-3-like protease – caspase 8, apoptosis-related cysteine protease – Fas-linked ICE-like protease – caspase 8, apoptosis-related cysteine peptidase – caspase-8a – cysteine protease – caspase-8 – death related ced-3/Nedd2-like protein – GLEAN_14026 – caspase-8-like – DEATH effector domain caspase

Caspase 8, Apoptosis-Related Cysteine Peptidase erfüllt eine Reihe von Funktionen:

cysteine-type endopeptidase activity – identical protein binding – peptidase activity – cysteine-type peptidase activity – hydrolase activity – protein binding – cytokine receptor binding – growth factor activity

Caspase 8, Apoptosis-Related Cysteine Peptidase spielt in den folgenden Prozessen eine Rolle:

activation of pro-apoptotic gene products – induction of apoptosis by extracellular signals – positive regulation of I-kappaB kinase/NF-kappaB cascade – proteolysis involved in cellular protein catabolic process – regulation of apoptosis – response to tumor necrosis factor – angiogenesis – apoptosis – heart development – macrophage differentiation – neural tube formation – proteolysis – positive regulation of apoptosis – protein heterooligomerization – response to antibiotic – response to cobalt ion – response to cold – response to estradiol stimulus – response to ethanol – response to lipopolysaccharide – immune response

Caspase 8, Apoptosis-Related Cysteine Peptidase ist wie folgt lokalisiert:

cytoplasm – cytoskeleton – cytosol – death-inducing signaling complex – mitochondrial outer membrane – mitochondrion – nucleus – Noc1p-Noc2p complex – membrane raft – protein complex – extracellular region

Quelle: NCBI Entrez Gene, Gene Ontology