Die folgenden Gennamen und Gensymbole werden für Antigen Carboxylesterase 1 über verschiedene Spezies hinweg verwendet:

carboxylesterase 1 (monocyte/macrophage serine esterase 1) (CES1), carboxylesterase 1 (Ces1), esterase 1 (Es1), esterase 22 (Es22), carboxylesterase 1 (CES1), liver carboxylesterase 1 (CpipJ_CPIJ013026), liver carboxylesterase 1 (CpipJ_CPIJ016339), liver carboxylesterase (LOC100009551), acetyl-Coenzyme A acetyltransferase 1 (ACAT1), sterol O-acyltransferase 1 (SOAT1), sterol O-acyltransferase 1 (Soat1), acetyl-coenzyme A acetyltransferase 1 (Acat1), acetyl-Coenzyme A acetyltransferase 1 (Acat1), acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) (ACAT1), acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) (acat1), MGC107795 protein (MGC107795), acetyl-CoA acetyltransferase 1 (ACAT1)

Zu den weiteren Synonymen zählen:

CEH, TGH, ACAT, CES2, HMSE, SES1, HMSE1, PCE-1, MGC117365, Ces-1, Ses-1, Es2, MGC109055, Ces1, MGC156521, CES1, CESDD1, CES-K1, LOC100009551, T2, MAT, THIL, SOAT, STAT, ACACT, ACAT1, RP11-215I23.2, ald, Acact, ACAT-1, AW550831, 8430426K15Rik, RATACAL, Acat-1, Acat, 6330585C21Rik, fd16h07, fd20g06, zgc:86832, wu:fd16h07, wu:fd20g06, MGC137917, MGC107795, acat1

Auf Proteinebene tauchen folgende Bezeichner für Antigen Carboxylesterase 1 auf:

carboxylesterase 1 – egasyn – liver carboxylesterase – triacylglycerol hydrolase – carboxylesterase 2 (liver) – cholesteryl ester hydrolase – acyl coenzyme A:cholesterol acyltransferase – OTTMUSP00000029370 – esterase 1 – E1 – REH – NREH – ES-THET – esterase-2 – carboxyesterase ES-1 – retinyl ester hydrolase – liver carboxylesterase 1 – neutral retinyl ester hydrolase – Esterase 2 member of carboxylesterase-cluster 1 – esterase 2, member of carboxylesterase-cluster 1 – esterase 22 – carboxylesterase D1 – acetyl-Coenzyme A acetyltransferase 1 – acetoacetyl Coenzyme A thiolase – mitochondrial acetoacetyl-CoA thiolase – sterol O-acyltransferase 1 – acyl-Coenzyme A: cholesterol acyltransferase – sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 – adrenocortical lipid depletion – Acetyl-Co A acetyltransferase 1 mitochondrial – Acetyl-Co A acetyltransferase 1, mitochondrial – acyl-coenzyme A:cholesterol acyltransferase – acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) – MGC107795 protein – Acetoacetyl-CoA thiolase – Acetyl-CoA acetyltransferase, mitochondrial – acyl-CoA:cholesterol acyltransferase – acetyl-CoA acetyltransferase 1 – acetyl-CoA acetyltransferase, mitochondrial-like

Carboxylesterase 1 erfüllt eine Reihe von Funktionen:

carboxylesterase activity – hydrolase activity – hydrolase activity, acting on ester bonds – palmitoyl-CoA hydrolase activity – acetyl-CoA C-acetyltransferase activity – acetyltransferase activity – metal ion binding – potassium ion binding – protein binding – transferase activity – acyl-CoA binding – acyltransferase activity – cholesterol O-acyltransferase activity – cholesterol binding – ergosterol O-acyltransferase activity – lanosterol O-acyltransferase activity – sterol O-acyltransferase activity – molecular_function – phosphatidylcholine-sterol O-acyltransferase activity – catalytic activity – transferase activity, transferring acyl groups other than amino-acyl groups

Carboxylesterase 1 spielt in den folgenden Prozessen eine Rolle:

metabolic process – response to toxin – cholesterol efflux – cholesterol esterification – cholesterol homeostasis – cholesterol metabolic process – cholesterol storage – lipid metabolic process – macrophage derived foam cell differentiation – positive regulation of amyloid precursor protein biosynthetic process – steroid metabolic process – very-low-density lipoprotein particle assembly – biological_process

Carboxylesterase 1 ist wie folgt lokalisiert:

endoplasmic reticulum – endoplasmic reticulum lumen – extracellular space – microsome – mitochondrial matrix – mitochondrion – endoplasmic reticulum membrane – integral to membrane – membrane – cellular_component – mitochondrial inner membrane

Quelle: NCBI Entrez Gene, Gene Ontology