Die folgenden Gennamen und Gensymbole werden für Antigen Calcitonin-Related Polypeptide alpha über verschiedene Spezies hinweg verwendet:

calcitonin-related polypeptide alpha (CALCA), CXXC finger 1 (PHD domain) (CXXC1), calcitonin/calcitonin-related polypeptide, alpha (CALCA), calcitonin (CT), Calcitonin gene-related peptide (calca), calcitonin (ci-ct)

Zu den weiteren Synonymen zählen:

CALCA, CALC3, MGC152154, CT, KC, CGRP, CALC1, CGRP1, CGRP-I, MGC126648, CFP1, CGBP, SPP1, PCCX1, PHF18, hCGBP, HsT2645, 2410002I16Rik, 5830420C16Rik, CALC, calcitonin, calca, ci-ct

Auf Proteinebene tauchen folgende Bezeichner für Antigen Calcitonin-Related Polypeptide alpha auf:

calcitonin – calcitonin-related polypeptide 3 – calcitonin-related polypeptide alpha – katacalcin – calcitonin 1 – calcitonin/calcitonin-related polypeptide, alpha – CXXC finger 1 (PHD domain) – CpG binding protein – DNA-binding protein with PHD finger and CXXC domain – Calcitonin gene-related peptide

Calcitonin-Related Polypeptide alpha erfüllt eine Reihe von Funktionen:

hormone activity – calcitonin receptor binding – DNA binding – metal ion binding – protein binding – transcription activator activity – unmethylated CpG binding – zinc ion binding

Calcitonin-Related Polypeptide alpha spielt in den folgenden Prozessen eine Rolle:

vasodilation – G-protein coupled receptor protein signaling pathway – activation of adenylate cyclase activity by G-protein signaling pathway – activation of protein kinase activity – cell-cell signaling – cytosolic calcium ion homeostasis – detection of temperature stimulus involved in sensory perception of pain – elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) – embryo implantation – endothelial cell migration – endothelial cell proliferation – feeding behavior – leukocyte adhesion – negative regulation of blood pressure – negative regulation of bone resorption – negative regulation of calcium ion transport into cytosol – negative regulation of neurological system process – negative regulation of ossification – negative regulation of osteoclast differentiation – negative regulation of smooth muscle contraction – negative regulation of transcription – neurological system process involved in regulation of systemic arterial blood pressure – neuropeptide signaling pathway – positive regulation of adenylate cyclase activity – positive regulation of cell adhesion – positive regulation of interleukin-1 alpha production – positive regulation of interleukin-8 production – positive regulation of macrophage differentiation – positive regulation of ossification – positive regulation of vasodilation – regulation of heart rate – regulation of inflammatory response – response to heat – response to pain – vasculature development – vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure – regulation of transcription, DNA-dependent

Calcitonin-Related Polypeptide alpha ist wie folgt lokalisiert:

extracellular region – axon – cell soma – cytoplasm – extracellular space – intracellular – nucleus – terminal button – nuclear matrix – nuclear speck

Quelle: NCBI Entrez Gene, Gene Ontology