Die folgenden Gennamen und Gensymbole werden für Antigen Cadherin 5 über verschiedene Spezies hinweg verwendet:

cadherin 1, type 1, E-cadherin (epithelial) (CDH1), cadherin 5 (Cdh5), protocadherin 12 (PCDH12), protocadherin 12 (Pcdh12), cadherin 5, type 2, VE-cadherin (vascular epithelium) (CDH5), cadherin 5, type 2 (vascular endothelium) (CDH5), cadherin 5 (CDH5), cadherin 5 (cdh5)

Zu den weiteren Synonymen zählen:

UVO, CDHE, ECAD, LCAM, Arc-1, CD324, 7B4, Vec, Cd144, VE-Cad, AA408225, VECAD2, VE-cadherin-2, Pcdh14, VE-cad-2, CDH5, wu:fc88a07

Auf Proteinebene tauchen folgende Bezeichner für Antigen Cadherin 5 auf:

cadherin 1, type 1 – uvomorulin – cell-CAM 120/80 – cadherin 1, E-cadherin (epithelial) – calcium-dependent adhesion protein, epithelial – cadherin 5 – VE-cadherin – 7B4/cadherin-5 – protocadherin 12 – VE-cadherin 2 – vascular cadherin-2 – vascular endothelial cadherin 2 – VE-cadherin-2 – protocadherin 14 – vascular endothelial cadherin-2 – cadherin 5, type 2, VE-cadherin (vascular epithelium) – cadherin 5, type 2, VE-cadherin (vascular endothelium) – cadherin 5, type 2 – vascular endothelial cadherin – VE cadherin – type 2 – fc88a07 – VE-cadherin (vascular epithelium) – cadherin 5, type 2 (vascular endothelium)

Cadherin 5 erfüllt eine Reihe von Funktionen:

calcium ion binding – cell adhesion molecule binding – transcription activator activity – RPTP-like protein binding – protein binding – protein phosphatase binding – receptor binding

Cadherin 5 spielt in den folgenden Prozessen eine Rolle:

homophilic cell adhesion – positive regulation of transcription factor import into nucleus – blood vessel maturation – cell adhesion – cell-cell adhesion – negative regulation of cell proliferation – calcium-dependent cell-cell adhesion – neuron recognition – glycogen metabolic process – labyrinthine layer development

Cadherin 5 ist wie folgt lokalisiert:

Golgi apparatus – actin cytoskeleton – catenin complex – cell junction – cell-cell adherens junction – cytoplasm – focal adhesion – integral to membrane – lateral plasma membrane – perinuclear region of cytoplasm – plasma membrane – cell-cell junction – membrane – tight junction – integral to plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology