Die folgenden Gennamen und Gensymbole werden für Antigen CD40 Ligand über verschiedene Spezies hinweg verwendet:

CD40 ligand (CD40LG), CD40 ligand (Cd40lg), CD40 ligand (CD154), CD40 ligand (cd40l), CD40 ligand (LOC100358388), TNF superfamily member 5 (cd40l), CD40 molecule, TNF receptor superfamily member 5 (CD40)

Zu den weiteren Synonymen zählen:

IGM, IMD3, TRAP, gp39, CD154, CD40L, HIGM1, T-BAM, TNFSF5, hCD40L, Ly62, Cd40l, Ly-62, Tnfsf5, CD40LG, cd40l

Auf Proteinebene tauchen folgende Bezeichner für Antigen CD40 Ligand auf:

CD40 ligand – CD40 antigen ligand – T-B cell-activating molecule – TNF-related activation protein – tumor necrosis factor (ligand) superfamily member 5 – CD40-L – OTTMUSP00000019349 – T-cell antigen Gp39 – tumor necrosis factor ligand superfamily member 5 – tumor necrosis factor (ligand) superfamily, member 5 – CD40 ligand CD154 – CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) – CD154 protein – human : hyper-IgM syndrome – TNF superfamily member 5 – tumor necrosis factor receptor superfamily member 5 – human CD40-homologue – CD40 antigen (TNF receptor superfamily member 5)

CD40 Ligand erfüllt eine Reihe von Funktionen:

CD40 receptor binding – cytokine activity – tumor necrosis factor receptor binding – molecular_function – receptor activity

CD40 Ligand spielt in den folgenden Prozessen eine Rolle:

B cell proliferation – anti-apoptosis – immune response – inflammatory response – isotype switching – leukocyte adhesion – platelet activation – positive regulation of interleukin-12 production – B cell differentiation – immunoglobulin secretion – positive regulation of B cell proliferation – positive regulation of MHC class II biosynthetic process – positive regulation of immune response to tumor cell – positive regulation of interferon-gamma production – positive regulation of interleukin-10 production – regulation of immunoglobulin secretion – signal transduction – biological_process

CD40 Ligand ist wie folgt lokalisiert:

extracellular region – extracellular space – integral to plasma membrane – plasma membrane – soluble fraction – integral to membrane – membrane – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology