Die folgenden Gennamen und Gensymbole werden für Antigen Integrin beta 2 über verschiedene Spezies hinweg verwendet:

integrin beta 2 (Itgb2), integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2), integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3), integrin beta 3 (Itgb3), integrin, beta 2 (ITGB2), integrin, beta 2 (Itgb2)

Zu den weiteren Synonymen zählen:

2E6, LAD, Cd18, Lfa1, MF17, LCAMB, AI528527, CD18, MFI7, LFA-1, MAC-1, CD61, GP3A, GPIIIa, INGRB3, MGC159221, MGC159223, ITGB2, integrin, ITGB3, MGC116306

Auf Proteinebene tauchen folgende Bezeichner für Antigen Integrin beta 2 auf:

integrin beta 2 – Mac-1 beta – OTTMUSP00000021575 – macrophage antigen-1 beta – lymphocyte function associated antigen 1 – integrin, beta 2 – OTTHUMP00000115279 – OTTHUMP00000115281 – OTTHUMP00000115282 – integrin beta chain, beta 2 – complement receptor C3 beta-subunit – leukocyte cell adhesion molecule CD18 – leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C – cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor) – integrin beta chain, beta 3 – platelet glycoprotein IIIa – integrin beta 3 – platelet gpIIIa – OTTMUSP00000003116 – integrin beta 3 (Cd61) – CD18 subunit – Leu-CAM receptor – integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2) – integrin, beta 3 – integrin beta 2 subunit – integrin beta-2 – CD18 leukocyte adhesion molecule – beta3 integrin – glycoprotein GPIIIa – antigen CD18 – integrin beta-2 chain – integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)

Integrin beta 2 erfüllt eine Reihe von Funktionen:

binding – protein binding – receptor activity – glycoprotein binding – protein kinase binding – identical protein binding – integrin binding – peptide binding – protein heterodimerization activity – cell adhesion molecule binding

Integrin beta 2 spielt in den folgenden Prozessen eine Rolle:

activated T cell proliferation – cell adhesion – cell-matrix adhesion – cellular extravasation – integrin-mediated signaling pathway – neutrophil chemotaxis – apoptosis – cell-cell signaling – inflammatory response – leukocyte adhesion – regulation of cell shape – regulation of peptidyl-tyrosine phosphorylation – blood coagulation – cell-substrate junction assembly – interspecies interaction between organisms – negative regulation of lipid storage – negative regulation of lipid transport – negative regulation of lipoprotein metabolic process – negative regulation of low-density lipoprotein receptor biosynthetic process – negative regulation of macrophage derived foam cell differentiation – regulation of cell migration – cellular calcium ion homeostasis – positive regulation of MAPKKK cascade – regulation of G-protein coupled receptor protein signaling pathway – cell-cell adhesion – endothelial cell migration – leukocyte cell-cell adhesion – leukocyte migration involved in inflammatory response – natural killer cell activation – positive regulation of NF-kappaB transcription factor activity – positive regulation of angiogenesis – positive regulation of nitric oxide biosynthetic process

Integrin beta 2 ist wie folgt lokalisiert:

cell surface – integral to membrane – integrin complex – membrane – membrane fraction – membrane raft – cytoplasm – plasma membrane – external side of plasma membrane – platelet alpha granule membrane

Quelle: NCBI Entrez Gene, Gene Ontology