Die folgenden Gennamen und Gensymbole werden für Antigen B-Cell CLL/lymphoma 2 über verschiedene Spezies hinweg verwendet:

B-cell CLL/lymphoma 2 (BCL2), B-cell CLL/lymphoma 2 (Bcl2), B-cell CLL/lymphoma 2 (LOC100224888)

Zu den weiteren Synonymen zählen:

Bcl-2, bcl-2, BCL2

Auf Proteinebene tauchen folgende Bezeichner für Antigen B-Cell CLL/lymphoma 2 auf:

B-cell lymphoma protein 2 – OTTHUMP00000163680 – B-cell CLL/lymphoma 2 – Bcl2-like protein – B-cell leukemia/lymphoma 2 – B cell lymphoma 2 associated oncogene – PCKBCL2 – BCL2B-cell CLL/lymphoma 2

B-Cell CLL/lymphoma 2 erfüllt eine Reihe von Funktionen:

BH3 domain binding – protease binding – protein heterodimerization activity – protein homodimerization activity – transcription activator activity – transcription factor binding – protein binding

B-Cell CLL/lymphoma 2 spielt in den folgenden Prozessen eine Rolle:

B cell homeostasis – B cell lineage commitment – B cell proliferation – CD8-positive, alpha-beta T cell lineage commitment – G1/S transition of mitotic cell cycle – T cell differentiation in the thymus – T cell homeostasis – T cell lineage commitment – actin filament organization – activation of pro-apoptotic gene products – anti-apoptosis – apoptosis in response to endoplasmic reticulum stress – axon regeneration – behavioral fear response – branching involved in ureteric bud morphogenesis – cell aging – cell death – cell morphogenesis – cell-cell adhesion – cochlear nucleus development – defense response to virus – developmental growth – ear development – endoplasmic reticulum calcium ion homeostasis – female pregnancy – focal adhesion formation – gland morphogenesis – glomerulus development – gut morphogenesis – hair follicle morphogenesis – hemopoiesis – homeostasis of number of cells within a tissue – humoral immune response – immune system development – lymphoid progenitor cell differentiation – male gonad development – melanin metabolic process – mesenchymal cell development – negative regulation of calcium ion transport into cytosol – negative regulation of cell growth – negative regulation of cell migration – negative regulation of cellular pH reduction – negative regulation of mitochondrial depolarization – negative regulation of mitotic cell cycle – negative regulation of myeloid cell apoptosis – negative regulation of neuron apoptosis – negative regulation of ossification – negative regulation of osteoblast proliferation – negative regulation of retinal cell programmed cell death – oocyte development – organ growth – organ morphogenesis – ovarian follicle development – oxygen and reactive oxygen species metabolic process – peptidyl-threonine phosphorylation – pigment granule organization – positive regulation of catalytic activity – positive regulation of cell proliferation – positive regulation of melanocyte differentiation – positive regulation of multicellular organism growth – positive regulation of neuron maturation – positive regulation of peptidyl-serine phosphorylation – positive regulation of pigmentation during development – positive regulation of skeletal muscle fiber development – positive regulation of smooth muscle cell migration – post-embryonic development – protein amino acid dephosphorylation – regulation of calcium ion transport – regulation of cell cycle – regulation of cell-matrix adhesion – regulation of gene expression – regulation of glycoprotein biosynthetic process – regulation of mitochondrial membrane permeability – regulation of mitochondrial membrane potential – regulation of nitrogen utilization – regulation of protein heterodimerization activity – regulation of protein homodimerization activity – regulation of protein localization – regulation of protein stability – regulation of viral genome replication – release of cytochrome c from mitochondria – renal system process – response to UV-B – response to acid – response to caffeine – response to cytokine stimulus – response to drug – response to estrogen stimulus – response to ethanol – response to external stimulus – response to gamma radiation – response to glucocorticoid stimulus – response to heat – response to hydrogen peroxide – response to hypoxia – response to inorganic substance – response to iron ion – response to nicotine – response to nutrient – response to oxidative stress – response to peptide hormone stimulus – response to protein stimulus – response to radiation – response to toxin – spleen development – thymus development – ureteric bud development – B cell differentiation – T cell differentiation – aging – apoptosis – axonogenesis – cell growth – cell proliferation – cellular calcium ion homeostasis – growth – kidney development – leukocyte homeostasis – lymphocyte homeostasis – melanocyte differentiation – metanephros development – negative regulation of apoptosis – negative regulation of cell proliferation – neuron apoptosis – ossification – peptidyl-serine phosphorylation – pigmentation during development – regulation of apoptosis – regulation of catalytic activity – regulation of pigmentation during development – regulation of programmed cell death – response to L-ascorbic acid – response to aluminum ion – response to cAMP – response to chemical stimulus – response to copper ion – response to corticosterone stimulus – response to folic acid – response to insulin stimulus – response to organic cyclic substance – response to organic substance – response to steroid hormone stimulus – response to stress

B-Cell CLL/lymphoma 2 ist wie folgt lokalisiert:

calcineurin complex – cytoplasm – cytosol – endoplasmic reticulum – endoplasmic reticulum membrane – integral to membrane – intracellular – membrane – membrane fraction – microsome – mitochondrial outer membrane – mitochondrion – myelin sheath – nuclear membrane – nucleus – protein phosphatase type 2A complex – mitochondrial membrane

Quelle: NCBI Entrez Gene, Gene Ontology