Die folgenden Gennamen und Gensymbole werden für Antigen ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 3 über verschiedene Spezies hinweg verwendet:

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 (ARAP3), ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 (Arap3), ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 (arap3), centaurin, delta 3 (Centd3), centaurin, delta 3 (CENTD3)

Zu den weiteren Synonymen zählen:

DRAG1, CENTD3, FLJ21065, Drag1, Centd3, AI851258, KIAA4097, mKIAA4097, E030006K04Rik, ARAP3, RGD1304938

Auf Proteinebene tauchen folgende Bezeichner für Antigen ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 3 auf:

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 – centaurin, delta 3 – PtdIns(3,4,5)P3-binding protein – phosphoinositide binding protein – Arf and Rho GAP adapter protein 3 – ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3 – dual-specificity Rho- and Arf-GTPase activating protein 1 – ARF-GAP, RHO-GAP, ankyrin repeat and pleckstrin homology domains-containing protein 3 – arfgap1 – arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3-like

ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 3 erfüllt eine Reihe von Funktionen:

ARF GTPase activator activity – Rac GTPase activator activity – metal ion binding – phosphatidylinositol-3,4,5-trisphosphate binding – phosphatidylinositol-3,4-bisphosphate binding – zinc ion binding – GTPase activator activity – Rho GTPase activator activity – protein binding

ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 3 spielt in den folgenden Prozessen eine Rolle:

cytoskeleton organization – negative regulation of Rho protein signal transduction – negative regulation of cell migration – regulation of ARF GTPase activity – regulation of cell shape – signal transduction – vesicle-mediated transport – negative regulation of Rac protein signal transduction

ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 3 ist wie folgt lokalisiert:

cytoplasm – cytoskeleton – extrinsic to membrane – intracellular – lamellipodium – plasma membrane – ruffle – cell projection – membrane

Quelle: NCBI Entrez Gene, Gene Ontology