Die folgenden Gennamen und Gensymbole werden für Antigen Apolipoprotein E3 über verschiedene Spezies hinweg verwendet:

apolipoprotein E (APOE)

Zu den weiteren Synonymen zählen:

AD2, LPG, LDLCQ5, MGC1571

Auf Proteinebene tauchen folgende Bezeichner für Antigen Apolipoprotein E3 auf:

apolipoprotein E – apolipoprotein E3

Apolipoprotein E3 erfüllt eine Reihe von Funktionen:

antioxidant activity – beta-amyloid binding – cholesterol transporter activity – heparin binding – lipid transporter activity – lipoprotein binding – low-density lipoprotein receptor binding – metal chelating activity – phosphatidylcholine-sterol O-acyltransferase activator activity – phospholipid binding – protein heterodimerization activity – protein homodimerization activity – tau protein binding – very-low-density lipoprotein receptor binding

Apolipoprotein E3 spielt in den folgenden Prozessen eine Rolle:

Cdc42 protein signal transduction – G-protein coupled receptor protein signaling pathway – anti-apoptosis – artery morphogenesis – cGMP-mediated signaling – cellular calcium ion homeostasis – cholesterol catabolic process – cholesterol homeostasis – chylomicron remnant clearance – cytoskeleton organization – high-density lipoprotein particle assembly – high-density lipoprotein particle clearance – high-density lipoprotein particle remodeling – induction of apoptosis – intracellular transport – lipid homeostasis – lipid metabolic process – lipid transport – lipoprotein biosynthetic process – lipoprotein catabolic process – maintenance of location in cell – negative regulation of MAP kinase activity – negative regulation of blood vessel endothelial cell migration – negative regulation of cholesterol biosynthetic process – negative regulation of endothelial cell proliferation – negative regulation of inflammatory response – negative regulation of platelet activation – nitric oxide mediated signal transduction – phospholipid efflux – positive regulation of cGMP biosynthetic process – positive regulation of cholesterol efflux – positive regulation of cholesterol esterification – positive regulation of low-density lipoprotein receptor catabolic process – positive regulation of membrane protein ectodomain proteolysis – positive regulation of nitric-oxide synthase activity – receptor-mediated endocytosis – regulation of axon extension – regulation of gene expression – regulation of neuronal synaptic plasticity – response to dietary excess – response to ethanol – response to reactive oxygen species – reverse cholesterol transport – synaptic transmission, cholinergic – triglyceride metabolic process – vasodilation – very-low-density lipoprotein particle clearance – very-low-density lipoprotein particle remodeling

Apolipoprotein E3 ist wie folgt lokalisiert:

Golgi apparatus – cell soma – chylomicron – cytoplasm – dendrite – extracellular region – extracellular space – extrinsic to external side of plasma membrane – high-density lipoprotein particle – intermediate-density lipoprotein particle – low-density lipoprotein particle – plasma membrane – very-low-density lipoprotein particle

Quelle: NCBI Entrez Gene, Gene Ontology