Die folgenden Gennamen und Gensymbole werden für Antigen Amyloid beta (A4) Precursor Protein über verschiedene Spezies hinweg verwendet:

beta amyloid protein precursor-like (Appl), amyloid beta (A4) precursor protein (APP), amyloid beta (A4) precursor protein (App), amyloid beta (A4) precursor protein (app)

Zu den weiteren Synonymen zählen:

APP, APP-like, APPL, Abeta, BcDNA:GH04413, EG:65F1.5, DmelCG7727, CG7727, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, CTFgamma, aaa, ad1, pn2, abpp, appi, cvap, abeta, MGC88882, ctfgamma

Auf Proteinebene tauchen folgende Bezeichner für Antigen Amyloid beta (A4) Precursor Protein auf:

beta amyloid protein precursor-like – CG7727-PA – Appl-PA – amyloid precursor protein – beta-amyloid-protein-precursor-like – amyloid beta A4 protein – protease nexin-II – OTTHUMP00000096096 – peptidase nexin-II – beta-amyloid peptide – cerebral vascular amyloid peptide – amyloid protein – Amyloid beta A4 protein – amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) – Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) – amyloid beta (A4) precursor protein – AG – ABPP – amyloidogenic glycoprotein – alzheimer disease amyloid A4 protein homolog – beta-amyloid precursor protein – amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) – amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease)

Amyloid beta (A4) Precursor Protein erfüllt eine Reihe von Funktionen:

protein binding – acetylcholine receptor binding – copper ion binding – heparin binding – identical protein binding – iron ion binding – metal ion binding – peptidase inhibitor activity – serine-type endopeptidase inhibitor activity – zinc ion binding – DNA binding – binding – peptidase activator activity – receptor binding

Amyloid beta (A4) Precursor Protein spielt in den folgenden Prozessen eine Rolle:

nervous system development – neuron projection morphogenesis – peripheral nervous system development – response to axon injury – synapse organization – Notch signaling pathway – cell adhesion – cell death – cellular copper ion homeostasis – endocytosis – neuromuscular process – neuron apoptosis – G2 phase of mitotic cell cycle – adult locomotory behavior – axon cargo transport – axon midline choice point recognition – axonogenesis – collateral sprouting in the absence of injury – dendrite development – extracellular matrix organization – forebrain development – ionotropic glutamate receptor signaling pathway – mRNA polyadenylation – mating behavior – neuromuscular process controlling balance – neuron remodeling – positive regulation of mitotic cell cycle – positive regulation of transcription from RNA polymerase II promoter – protein amino acid phosphorylation – regulation of epidermal growth factor receptor activity – regulation of multicellular organism growth – regulation of synapse structure and activity – regulation of translation – smooth endoplasmic reticulum calcium ion homeostasis – suckling behavior – synaptic growth at neuromuscular junction – visual learning – induction of apoptosis – locomotory behavior – neuron projection development

Amyloid beta (A4) Precursor Protein ist wie folgt lokalisiert:

extracellular region – integral to membrane – plasma membrane – Golgi apparatus – cell surface – coated pit – cytoplasm – integral to plasma membrane – platelet alpha granule lumen – apical part of cell – axon – ciliary rootlet – cytoplasmic vesicle – membrane fraction – neuromuscular junction – perinuclear region of cytoplasm – spindle midzone – dendritic shaft – dendritic spine – membrane – neuron projection – synapse – synaptosome

Quelle: NCBI Entrez Gene, Gene Ontology