Die folgenden Gennamen und Gensymbole werden für Antigen Adenomatous Polyposis Coli über verschiedene Spezies hinweg verwendet:

adenomatous polyposis coli (APC), adenomatous polyposis coli (Apc), adenomatous polyposis coli (apc), adenomatous polyposis coli protein (Smp_139190)

Zu den weiteren Synonymen zählen:

GS, DP2, DP3, BTPS2, DP2.5, RATAPC, APC, MGC140121, dp2, dp3, fap, fpc, xapc, dp2.5

Auf Proteinebene tauchen folgende Bezeichner für Antigen Adenomatous Polyposis Coli auf:

adenomatous polyposis coli – adenomatosis polyposis coli tumor suppressor – adenomatous polyposis coli protein – adenomatosis polyposis coli – adenomatous polyposis coli protein-like

Adenomatous Polyposis Coli erfüllt eine Reihe von Funktionen:

beta-catenin binding – microtubule binding – protein kinase binding – protein kinase regulator activity – cadherin binding – gamma-catenin binding – microtubule plus-end binding – protein binding

Adenomatous Polyposis Coli spielt in den folgenden Prozessen eine Rolle:

T cell differentiation in the thymus – Wnt receptor signaling pathway through beta-catenin – anterior/posterior pattern formation – axis specification – axonogenesis – cell cycle arrest – chromosome organization – cytokinesis after mitosis – dorsal/ventral pattern formation – hair follicle development – kidney development – mitotic cell cycle spindle assembly checkpoint – mitotic metaphase/anaphase transition – muscle homeostasis – negative regulation of MAPKKK cascade – negative regulation of Wnt receptor signaling pathway – negative regulation of apoptosis – negative regulation of cyclin-dependent protein kinase activity – negative regulation of epithelial cell proliferation – negative regulation of microtubule depolymerization – negative regulation of odontogenesis – positive regulation of apoptosis – positive regulation of cell adhesion – positive regulation of cell division – positive regulation of cell migration – positive regulation of epithelial cell differentiation – positive regulation of microtubule polymerization – positive regulation of protein catabolic process – positive regulation of pseudopodium assembly – protein complex assembly – proximal/distal pattern formation – regulation of attachment of spindle microtubules to kinetochore – regulation of cell cycle – regulation of nitrogen compound metabolic process – regulation of osteoblast differentiation – regulation of osteoclast differentiation – response to DNA damage stimulus – retina development in camera-type eye – skin development – somatic stem cell maintenance – thymus development – tight junction assembly – Wnt receptor signaling pathway – canonical Wnt receptor signaling pathway – cell migration – establishment or maintenance of cell polarity – muscle cell homeostasis – negative regulation of canonical Wnt receptor signaling pathway – negative regulation of cell proliferation – negative regulation of epithelial cell proliferation involved in prostate gland development – neuron projection development – pancreas development – pattern specification process – positive regulation of cell differentiation – regulation of apoptosis – regulation of cell differentiation – regulation of cell migration – regulation of epithelial cell differentiation – response to drug – stem cell maintenance

Adenomatous Polyposis Coli ist wie folgt lokalisiert:

Axin-APC-beta-catenin-GSK3B complex – axon part – beta-catenin destruction complex – cell projection – cell projection membrane – centrosome – cytoplasm – cytoplasmic microtubule – cytosol – growth cone – kinetochore – lateral plasma membrane – nucleus – tight junction – cell junction – cell-cell adherens junction – microtubule – neuron projection – neuronal cell body – synapse

Quelle: NCBI Entrez Gene, Gene Ontology