Die folgenden Gennamen und Gensymbole werden für Antigen Actinin, alpha 2 über verschiedene Spezies hinweg verwendet:

actinin, alpha 2 (ACTN2), CDC5 cell division cycle 5-like (S. pombe) (CDC5L), actinin alpha 2 (Actn2), actinin alpha 3a (actn3a), actinin, alpha 2 (actn2)

Zu den weiteren Synonymen zählen:

CMD1AA, CEF1, hCDC5, PCDC5RP, KIAA0432, dJ319D22.1, MGC107582, 1110008F24Rik, ACTN2, actn3, actnl, MGC63559, zgc:63559, MGC79034, MGC89234, MGC128123, MGC123223, wu:fd44c03, zgc:123223

Auf Proteinebene tauchen folgende Bezeichner für Antigen Actinin, alpha 2 auf:

actinin, alpha 2 – F-actin cross-linking protein – alpha-actinin skeletal muscle – CDC5-like – Cdc5-related protein – dJ319D22.1 (CDC5-like protein) – Cell division cycle 5, S. pombe, homolog-like – CDC5 (cell division cycle 5, S. pombe, homolog)-like – actinin alpha 2 – OTTMUSP00000018506 – actinin alpha 3a – actinin like – actinin alpha 3 – alpha-actinin – fd44c03 – alpha 2 actinin – actinin, alpha 2-like – alpha-actinin-2-like

Actinin, alpha 2 erfüllt eine Reihe von Funktionen:

FATZ 1 binding – ZASP binding – actin binding – calcium ion binding – identical protein binding – integrin binding – protein dimerization activity – structural constituent of muscle – thyroid hormone receptor coactivator activity – titin Z domain binding – titin binding – DNA binding – RNA binding – protein binding – actin filament binding – ligand-dependent nuclear receptor transcription coactivator activity – protein binding, bridging – protein homodimerization activity

Actinin, alpha 2 spielt in den folgenden Prozessen eine Rolle:

cell adhesion – focal adhesion formation – microspike assembly – muscle contraction – protein homotetramerization – regulation of apoptosis – RNA splicing – cell cycle – mRNA processing – regulation of transcription, DNA-dependent – cellular_component

Actinin, alpha 2 ist wie folgt lokalisiert:

Z disc – actin filament – cytoplasm – cytoskeleton – dendritic spine – extracellular region – filopodium – focal adhesion – nucleolus – platelet alpha granule lumen – pseudopodium – nuclear speck – nucleus – spliceosomal complex – striated muscle thin filament – cortical actin cytoskeleton – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology